Bone morphogenetic protein (BMP) signaling determines neuroblastoma cell fate and sensitivity to retinoic acid.
M. Pan, Y. Zhang, W. C. Wright, X. Liu, B. Passaia, D. Currier, R. H. Chapple, J. Steele, J. P. Connelly, M. Lu, H.-M. Lee, A. Loughran, L. Yang, B. J. Abraham, S. M. Pruett-Miller, , P. Geeleher
The paper investigates RA's limited effect on primary neuroblastoma tumors but efficacy in clearing bone marrow cells, identifying BMP signaling as a key determinant of cell fate and RA sensitivity.
bioRxiv · May 9, 2024Cancer Biology