Author

J. Steele

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Physiology· 2 Biophysics· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 4 Approach:experimental assay· 3 Organism:human· 3 Organism:mouse· 2 Assay:proteomics· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

B. Freeman· 2 shared A. Cortes· 1 shared A. D. Vigotsky· 1 shared A. Davidoff· 1 shared A. Loughran· 1 shared B. J. Abraham· 1 shared B. Passaia· 1 shared C. A. Timpani· 1 shared

Activity by Year

2021-2024 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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2 shared papersCancer Biology

B. Freeman

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Haptoglobin and glutamine synthetase may biomark cachexia induced by anti-acute myeloid leukemia chemotherapy

D. G. Campelj, C. A. Timpani, G. Spiesberger, L. E. Formosa, J. Steele, H. Zhang, R. B. Schittenhelm, L. Leow, C. Goodman, E. Rybalka

This study shows that the AML chemotherapy regimen induces cachexia in mice, characterized by body and lean mass loss, and identifies haptoglobin as a potential biomarker for chemotherapy-induced cachexia.

bioRxiv · Jul 24, 2024 · PreprintPhysiology

Bone morphogenetic protein (BMP) signaling determines neuroblastoma cell fate and sensitivity to retinoic acid.

M. Pan, Y. Zhang, W. C. Wright, X. Liu, B. Passaia, D. Currier, R. H. Chapple, J. Steele, J. P. Connelly, M. Lu, H.-M. Lee, A. Loughran, L. Yang, B. J. Abraham, S. M. Pruett-Miller, , P. Geeleher

The paper investigates RA's limited effect on primary neuroblastoma tumors but efficacy in clearing bone marrow cells, identifying BMP signaling as a key determinant of cell fate and RA sensitivity.

bioRxiv · May 9, 2024Cancer Biology

RBM39 degrader invigorates natural killer cells to eradicate neuroblastoma despite cancer cell plasticity

S. Singh, J. Fang, H. Jin, L.-A. Van de Velde, Q. Wu, A. Cortes, C. Morton, M. Woolard, W. Quarni, J. Steele, J. Connelly, L. He, R. Thorne, G. Turner, T. Confer, , J. Yang

This study shows that targeting RBM39 with indisulam promotes natural killer cell activity and eradicates neuroblastoma regardless of cellular state plasticity.

bioRxiv · Mar 21, 2024 · PreprintCancer Biology

Multi-Channel smFRET study reveals a Compact conformation of EF-G on the Ribosome

J. Johnson, J. Steele, R. Lin, V. Stepanov, M. Gavriliuc, y. wang

This study uses multi-channel smFRET to show that EF-G adopts a compact conformation with specific mutations, impacting translocation and Poly(Phe) synthesis.

bioRxiv · Jan 27, 2024Biophysics

Motor unit recruitment patterns of the quadriceps differ between continuous high- and low-torque isometric knee extension to momentary failure

J. Murphy, E. Hodson-Tole, A. D. Vigotsky, J. R. Potvin, J. P. Fisher, J. Steele

This study compares motor unit recruitment patterns during high- and low-torque isometric knee extensions to momentary failure using sEMG frequency analysis, finding similar overall recruitment but differing temporal patterns.

bioRxiv · Apr 8, 2021 · PreprintPhysiology