P. Fang

Jellyfish blooms - an overlooked hotspot and potential vector for the transmission of antimicrobial resistance in marine environments

This study shows that jellyfish blooms create a hotspot for antimicrobial resistance gene (ARG) transmission by promoting microbial growth and horizontal gene transfer in marine environments.

Cigarette smoking promotes the spread of antimicrobial resistance in the human lung and the environment

This study shows cigarette smoke increases antimicrobial resistance transfer between bacteria in lung and environmental settings.

Using artificial intelligence to document the hidden RNA virosphere

This study uses a deep learning algorithm to discover highly divergent RNA viruses in metatranscriptomes, identifying 161,979 potential species and 180 supergroups.

Microbiome diversity: A barrier to the environmental spread of antimicrobial resistance?

The paper investigates whether microbial diversity acts as a barrier to the spread of antimicrobial resistance genes in the environment, finding that higher diversity correlates with lower ARG abundance in structured soils but not in dynamic rivers.

Sex-dependent interactions between prodromal intestinal inflammation and LRRK2 G2019S in mice promote symptoms of Parkinson's disease

This study shows that intestinal inflammation worsens Parkinson's disease symptoms in male mice with the LRRK2 G2019S mutation, but not females, through sex-dependent mechanisms involving α-synuclein accumulation.

Coupled functional physiological phenotyping and simulation model to estimate dynamic water use efficiency and infer transpiration sensitivity traits

Understanding water conservation vs. profligation traits in vegetable legumes through a physio-transcriptomic-functional approach

This study compares water use strategies in soybean and cowpea under drought using phenomic and transcriptomic analyses, identifying gene networks and regulatory mechanisms underlying their contrasting responses.

Mapping the GALNT1 substrate landscape with versatile proteomics tools

This study identifies hundreds of novel GALNT1 substrates using proteomics tools, revealing preferences for Thr residues and Pro at positions +3 and +4, and implicating GALNT1 in diverse biological pathways.

DEAD-box RNA helicase 18 disrupts IRF3-binding to the interferon-β promoter

This study identifies DDX18 as a negative regulator of IRF3 binding to the IFN-β promoter, suppressing type I IFN production during viral infection.

Evaluation and Optimization of High-Field Asymmetric Waveform Ion Mobility Spectrometry for Multiplexed Quantitative Site-specific N-glycoproteomics

This study optimizes FAIMS settings for improved identification and quantification of site-specific N-glycopeptides using TMT labeling and Glyco-SPS-MS3 methods.

High throughput functional screening for next generation cancer immunotherapy using droplet-based microfluidics

This paper develops a droplet-based microfluidics platform for high-throughput functional antibody screening, identifying potent cancer immunotherapeutics like CD40 agonists and anti-Her2/anti-CD3 bispecific antibodies.

SugarQuant: a streamlined pipeline for multiplexed quantitative site-specific N-glycoproteomics

SugarQuant provides a pipeline for site-specific N-glycoproteomics, enabling confident quantification of glycoforms in complex samples.

An NKX2-1/ERK/WNT feedback loop modulates gastric identity and response to targeted therapy in lung adenocarcinoma