Author

A. Hao

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biochemistry· 2 Microbiology· 2 Biophysics· 1 Immunology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 6 Organism:bacteria (other)· 3 Assay:cryo-EM· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:protein structure prediction· 2 Assay:structural biology· 2 Research Focus:chromatin & epigenetic regulation· 1 Organism:human· 1

Frequent Co-Authors

W. Zhan· 3 shared X. ZhangiD· 3 shared Z. Chen· 3 shared L. SuniD· 2 shared M. Zhang· 2 shared Q. Liu· 2 shared S.-Y. Lee· 2 shared Y. Hu· 2 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersImmunology

W. Zhan

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Structural insights into the FtsEX-EnvC complex regulation on septal peptidoglycan hydrolysis in Vibrio cholerae

A. Hao, Y. Suo, S.-Y. Lee

The paper presents the cryo-EM structure of the FtsEX-EnvC complex from V. cholerae and shows how EnvC's conformational changes regulate amidase activity for septal peptidoglycan hydrolysis.

bioRxiv · Oct 6, 2023Biochemistry

Fortuitous Somatic Mutations during Antibody Evolution Endow Broad Neutralization against SARS-CoV-2 Omicron Variants

J. Wu, Z. Chen, Y. Gao, Z. Wang, J. Wang, B.-Y. Chiang, Y. Zhou, Y. Han, W. Zhan, M. Xie, W. Jiang, X. Zhang, A. Hao, A. Xia, J. He, , Q. Wang

The paper identifies an antibody with broad neutralization against SARS-CoV-2 Omicron variants and shows how somatic mutations enhance its neutralization breadth and potency.

Cell Reports · May 1, 2023Peer-reviewedImmunology

A potent SARS-CoV-2 antibody neutralizes Omicron variant by disassembling the spike trimer

L. Sun, W. Zhan, X. Tian, X. Zhang, S. Xing, W. Song, Q. Liu, A. Hao, Y. Hu, M. Zhang, Z. Chen, T. Ying, F. Lan

This paper identifies a potent SARS-CoV-2 antibody, 553-49, that neutralizes the Omicron variant by targeting a conserved epitope and disassembling spike trimers.

bioRxiv · Mar 21, 2022 · PreprintMicrobiology

Asymmetric Pendrin Homodimer Reveals its Molecular Mechanism as Anion Exchanger

Q. Liu, X. Zhang, H. Huang, Y. Chen, F. Wang, A. Hao, W. Zhan, Q. Mao, Y. Hu, L. Han, Y. Sun, M. Zhang, Z. Liu, G. Li, W. Zhang, , Z. Chen

The paper determines the asymmetric homodimer structure of mouse pendrin using cryo-EM, revealing its electroneutral anion exchange mechanism and pathogenetic mutation properties.

bioRxiv · Jan 14, 2022 · PreprintBiophysics

Molecular mechanism of regulation of the purine salvage enzyme XPRT by the alarmones pppGpp, ppGpp, and pGpp

B. W. Anderson, A. Hao, K. A. Satyshur, J. L. Keck, J. D. Wang

This study identifies how alarmones pppGpp, ppGpp, and pGpp inhibit XPRT activity by competing with PRPP, revealing structural and regulatory differences between XPRT and HPRT.

bioRxiv · Mar 4, 2020Microbiology

Visualizing Conformational Transitions of the Lipid II Flippase MurJ

A. C. Y. Kuk, A. Hao, Z. Guan, S.-Y. Lee

This study reports crystal structures of MurJ in different conformations to elucidate its mechanism of lipid flipping and identify a key ion for function.

bioRxiv · Feb 19, 2019 · PreprintBiochemistry