Mn2+-Induced Structural Flexibility Enhances the Entire Catalytic Cycle and the Cleavage of Mismatches in Prokaryotic Argonaute Proteins
L. Zheng, B. Zan, Y. Yang, B. Zhou, N. Li, B. Wu, F. Jiang, Y. Feng, Q. Liu, L. Hong
This study shows that Mn2+ enhances pAgo protein flexibility, improving catalytic efficiency and mismatch cleavage through structural changes.
bioRxiv · Jun 28, 2023Biophysics