Persistent Post-Inflammatory Matrix Stiffening Defines a Premalignant Mechanical Niche in Ulcerative Colitis-Associated Neoplasia
Ziwei Wang, Ning Xie, Beibei Xu, Jian Wu, Bo Cheng, Yutong Cheng, Haitao Shi, Qiuai Shu, Y Li, Xiru Liang, Ameng Shi, Yuxin Peng, Bin Qin, Mingxuan Song, Kairuo Wang, , Feng Xu
This study identifies persistent post-inflammatory matrix stiffening as a premalignant mechanical niche in UC-associated neoplasia, showing its role in epithelial remodeling and potential therapeutic targeting.
bioRxiv · Jun 19, 2026 · PreprintCancer Biology