Feng Xu

Matrix stiffness shapes immunometabolic states and response to PD-1 blockade in gastric cancer

This study shows that matrix stiffness in gastric cancer affects immunometabolic states and response to PD-1 blockade, with softer matrices improving treatment efficacy.

Persistent Post-Inflammatory Matrix Stiffening Defines a Premalignant Mechanical Niche in Ulcerative Colitis-Associated Neoplasia

This study identifies persistent post-inflammatory matrix stiffening as a premalignant mechanical niche in UC-associated neoplasia, showing its role in epithelial remodeling and potential therapeutic targeting.

Increased diffusion in livers with advanced fibrosis: pre-clinical and clinical observations with diffusion MRI

This paper investigates ADC and SDC changes in liver fibrosis using pre-clinical and clinical data, finding that SDC increases with fibrosis stage while ADC decreases.

A Conserved Geometric Code: Extracellular Matrix Curvature Directs Cell Migration Strategy via Nuclear Mechanosensing

The paper shows ECM curvature directs cell migration through nuclear mechanosensing, revealing a geometric code influencing migration strategy and metastasis.

Long-Read Transcriptome Sequencing and Functional Validation Reveals Novel and Oncogenic Gene Fusions in Fusion Panel-Negative Gliomas

The paper identifies novel oncogenic gene fusions in fusion-negative gliomas using long-read sequencing and functional validation in Drosophila.

Metabolic dysfunction related to specific genetic variant sites of methylmalonic acidemia

The paper investigates metabolic differences in methylmalonic acidemia subtypes caused by specific genetic variants, identifying enriched metabolites associated with each mutation.

Kidney cortex macrophages strategically reabsorb phosphate from the urine to prevent the formation of mineral stones

This study identifies kidney cortex macrophages as a novel source of phosphate reabsorption, preventing calcium phosphate stone formation by upregulating SLC34A1 in response to mineral crystals.