Evolutionary BiologybioRxiv
Homology-guided identification of a conserved motif linking the antiviral functions of IFITM3 to its oligomeric state
K. Rahman, C. A. Coomer, S. Majdoul…·A. A. Compton
This study identifies a conserved GxxxG motif in IFITM3 that drives oligomerization and antiviral activity by promoting membrane rigidity.
DOI 10.7554/elife.58537