Antiviral defense via nucleotide depletion in bacteria
N. Tal, A. Millman, A. Stokar-Avihail, T. Fedorenko, A. Leavitt, S. Melamed, E. Yirmiya, C. Abraham, G. Amitai, R. Sorek
This study identifies bacterial proteins that deplete specific deoxynucleotides to inhibit phage replication, mirroring the human SAMHD1 antiviral mechanism.
bioRxiv · Apr 26, 2021 · PreprintMicrobiology