CTLA-4 antibody-drug conjugate reveals autologous destruction of B-lymphocytes associated with regulatory T cell impairment
M. M. Muthana, X. Du, M. Liu, X. Wang, W. Wu, C. Ai, L. Su, P. Zheng, Y. Liu
The paper shows that anti-CTLA-4 ADC treatment causes B cell depletion via T cell hyper-proliferation and regulatory T cell impairment in CTLA-4 knock-in mice.
bioRxiv · Mar 1, 2023 · PreprintImmunology