Breakage fusion bridge cycles drive high oncogene copy number, but not intratumoral genetic heterogeneity or rapid cancer genome change
S. R. Dehkordi, I. T.-L. Wong, J. Ni, J. Luebeck, K. Zhu, G. Prasad, L. Krockenberger, G. Xu, B. Chowdhury, U. Rajkumar, A. Caplin, D. Muliaditan, C. Coruh, Q. Jin, K. Turner, , V. Bafna
The paper introduces OM2BFB, an algorithm detecting BFB amplifications using OGMs, showing high precision and recall, and finds BFB events are common in certain cancers but not linked to intratumoral heterogeneity or rapid genome change.
bioRxiv · Dec 12, 2023 · PreprintCancer Biology