Author

U. Rajkumar

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 4 Organism:human· 3 Research Focus:clustering· 2 Approach:deep learning· 2 Research Focus:gene regulatory network inference· 2 Assay:whole-genome sequencing· 2 Research Focus:cancer & tumor microenvironment· 1 Organism:chicken / avian· 1

Frequent Co-Authors

P. S. Mischel· 3 shared V. Bafna· 3 shared H. Y. Chang· 2 shared J. T. Lange· 2 shared K. E. Yost· 2 shared K. L. Hung· 2 shared Q. Shi· 2 shared S. Wu· 2 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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3 shared papersCancer Biology

P. S. Mischel

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Author profile →

4 papers

Recent·Most cited

Breakage fusion bridge cycles drive high oncogene copy number, but not intratumoral genetic heterogeneity or rapid cancer genome change

S. R. Dehkordi, I. T.-L. Wong, J. Ni, J. Luebeck, K. Zhu, G. Prasad, L. Krockenberger, G. Xu, B. Chowdhury, U. Rajkumar, A. Caplin, D. Muliaditan, C. Coruh, Q. Jin, K. Turner, , V. Bafna

The paper introduces OM2BFB, an algorithm detecting BFB amplifications using OGMs, showing high precision and recall, and finds BFB events are common in certain cancers but not linked to intratumoral heterogeneity or rapid genome change.

bioRxiv · Dec 12, 2023 · PreprintCancer Biology

Principles of ecDNA random inheritance drive rapid genome change and therapy resistance in human cancers

J. T. Lange, C. Y. Chen, Y. Pichugin, F. Xie, J. Tang, K. L. Hung, K. E. Yost, Q. Shi, M. L. Erb, U. Rajkumar, S. Wu, C. Swanton, Z. Liu, W. Huang, H. Y. Chang, , P. S. Mischel

bioRxiv · Jun 11, 2021 · PreprintCancer Biology

Indian Red Jungle fowl depicts close genetic relationship with Indian native chicken breeds as evidenced through whole mitochondrial genome intersection

M. Kanakachari, R. N. Chatterjee, U. Rajkumar, S. Haunshi, M. R. Reddy, T. Bhattacharya

The paper uses whole mitochondrial genome sequencing to show Indian Red Jungle fowl is the maternal ancestor of Indian native chicken breeds.

bioRxiv · Dec 29, 2020 · PreprintEvolutionary Biology

EcDNA hubs drive cooperative intermolecular oncogene expression

K. L. Hung, K. E. Yost, L. Xie, S. Wu, J. T. Lange, C. V. Duffy, K. Kraft, J. Tang, Q. Shi, J. C. Rose, M. R. Corces, J. M. Granja, R. Li, U. Rajkumar, R. Tjian, , H. Y. Chang

The paper identifies ecDNA hubs as nuclear structures that drive cooperative oncogene expression through intermolecular enhancer-promoter interactions and shows BET inhibitors can disrupt these hubs and kill cancer cells.

bioRxiv · Nov 19, 2020Cancer Biology