G. Xu

Exploring the therapeutic potential of a novel series of imidazothiadiazoles targeting focal adhesion kinase (FAK) for pancreatic cancer treatment: Synthesis, mechanistic Insights and promising antitumor and safety profile

This study identifies compound 10l as a potent FAK inhibitor with antitumor activity and safety in pancreatic cancer models.

Microbial community assembly during aging of food waste-derived hydrochar: key bacterial guilds mediate nutrient dynamics

This study investigates how adding straw and microbes accelerates hydrochar aging by identifying key bacterial guilds involved in nutrient cycling.

Mechano-regulation of GLP-1 production by Piezo1 in intestinal L cells

This study shows that Piezo1 in intestinal L cells mechanically regulates GLP-1 production, affecting glucose tolerance and diabetes.

In-depth investigation of the mechanisms of high and low residual feed intake regulating hens during the late laying period via liver and gut microbiota.

Hyperbaric Oxygen-Induced acute lung injury: A Mouse Model Study on Pathogenesis and Recovery Dynamics

This study investigates hyperbaric oxygen-induced acute lung injury in mice, showing that vascular endothelial damage is most severe and slowest to recover, with inflammation peaking 12 hours post-exposure.

SHOOTMERISTEMLESS autoactivation: A prerequisite for fruit metamorphosis

The paper shows that CrSTM autoactivation through a cis regulatory element is essential for Capsella fruit shape transition during metamorphosis.

Cortical microinfarcts potentiate recurrent ischemic injury through NLRP3-dependent trained immunity

This study shows that microinfarcts in mice enhance recurrent stroke severity via NLRP3-dependent trained immunity in microglia.

Breakage fusion bridge cycles drive high oncogene copy number, but not intratumoral genetic heterogeneity or rapid cancer genome change

The paper introduces OM2BFB, an algorithm detecting BFB amplifications using OGMs, showing high precision and recall, and finds BFB events are common in certain cancers but not linked to intratumoral heterogeneity or rapid genome change.

Structural insights into specific recognition of PTENα/β-NTE by WDR5 in cancer progression

The paper determines the crystal structure of PTEN-NTE bound to WDR5, revealing a specific binding motif that promotes tumor growth and suggests WDR5 inhibitors as potential cancer therapies.

A novel antagonist of the CCL5/CCR5 axis suppresses the tumor growth and metastasis of triple-negative breast cancer by CCR5-YAP1 regulation.

This study identifies verteporfin as a potent CCL5/CCR5 axis antagonist that suppresses TNBC tumor growth and metastasis through CCR5-YAP1 regulation.

Lymphotoxin-β Promotes Bone Colonization and Osteolytic Outgrowth of Indolent Bone Metastatic cells of Breast Cancer

This study identifies lymphotoxin-β as a key factor promoting bone colonization and osteolytic outgrowth of breast cancer metastatic cells.

Use of Artificial Intelligence for Automated Detection and Surveillance of Red Imported Fire Ants Nests

This study develops an AI system using robotic dogs to detect red imported fire ant nests with 95% precision, improving surveillance and pesticide delivery in open fields.

Rice OsHAK18 mediates shoot-to-root circulation of potassium and sodium and source-to-sink transport of soluble sugar

Rice OsHAK18 mediates shoot-to-root potassium and sodium circulation and source-to-sink sugar transport, improving potassium use efficiency and grain yield.

STING-dependent cytosolic DNA sensing pathway drives the progression to leukemia in TET2-mutated HSPCs

This study shows that TET2 mutations cause DNA damage, activating the cGAS-STING pathway, which drives clonal hematopoiesis and leukemia, and that STING inhibition can suppress these effects in mouse and patient models.

A Common Resequencing-Based Genetic Marker Dataset for Global Maize Diversity

The paper creates a unified genetic marker dataset from maize resequencing data to enhance the analysis of genetic diversity and functional allele frequency changes.

Deciphering the non-coding code of pathogenicity and sexual differentiation in the human malaria parasite.

This study identifies and characterizes long non-coding RNAs (lncRNAs) in Plasmodium falciparum, revealing their role in gene regulation, pathogenicity, and sexual differentiation.

Propagation dynamics of electrotactic motility in large epithelial cell sheets

The paper uses electric fields to induce migration in human keratinocyte sheets and develops an in silico model showing how directional cues propagate to drive coherent collective migration.

Novel insights into L-serine exporters in Corynebacterium glutamicum from gene mining and functional analysis

This study identifies NCgl0254 and NCgl0255 as novel O_SCPLOWLC_SCPLOW-serine exporters in C. glutamicum and shows that all four exporters (ThrE, SerE, NCgl0254, NCgl0255) are interdependent in O_SCPLOWLC_SCPLOW-serine export, with SerE being the major contributor.

Phase-separated TRB-PRC2 aggregates contribute to Polycomb silencing in plants

The paper shows that phase-separated TRB proteins aggregate with PRC2 to enhance Polycomb silencing in plants.

Dual-Resolving of Lipid Positional and Geometric Isomers of C=C Bonds via Bifunctional Photocycloaddition-Photoisomerization Reaction System and Mass Spectrometry

This paper develops a bifunctional reaction system to simultaneously resolve lipid positional and geometric isomers using mass spectrometry, revealing structural patterns in bacteria and tracking changes in mouse brain ischemia.

CD8 T Cell Memory Inflation is Driven by Latent CMV Infection of Lymphatic Endothelial Cells

The paper identifies lymphatic endothelial cells as the source of antigen presentation driving CD8 T cell memory inflation during latent CMV infection.

Structural basis for the neurotropic AAV9 and the engineered AAVPHP.eB recognition with cellular receptors

This study determines the cryo-EM structures of AAV9 and AAVPHP.eB in complex with their receptor AA VR, revealing molecular details of receptor recognition and explaining enhanced CNS transduction.

Interaction network of SARS-CoV-2 with host receptome through spike protein

This study identifies multiple SARS-CoV-2 receptors, including ASGR1 and KREMEN1, which enable virus entry and correlate with multi-organ tropism and clinical symptoms.

Maize root-associated microbes likely under adaptive selection by the host to enhance phenotypic performance

This study identifies plant genetic loci associated with rhizobiome composition in maize and shows host selection influences microbial abundance under different nitrogen conditions.

CAR modulates plasma membrane nano-organization and immune signaling downstream of RALF1-FERONIA signaling pathway

This study shows that the FER-CAR module regulates plasma membrane nano-organization and immune signaling through a feedback loop during RALF1 signaling.

Serum glycoprotein markers in non-alcoholic steatohepatitis and hepatocellular carcinoma

This study identifies serum glycoprotein markers that distinguish non-alcoholic steatohepatitis (NASH) and hepatocellular carcinoma (HCC) from healthy controls.

Gene losses may contribute to subterranean adaptations in naked mole-rat and blind mole-rat

This study identifies gene losses in subterranean rodents, showing their potential role in hypoxia tolerance and other adaptations.

A UAV-based high-throughput phenotyping approach to assess time-series nitrogen responses and identify traits associated genetic components in maize

This study uses UAV-based phenotyping to analyze maize nitrogen responses over time, identifying genetic regions and candidate genes associated with phenotypic traits.

Metabolic characteristics of taste differences under the soil and hydroponic cultures of sweet potato leaves by using non-targeted metabolomics

This study compares the metabolic profiles of sweet potato leaves grown in soil versus hydroponic systems to identify metabolites associated with taste quality differences.

The CLASSY family controls tissue-specific DNA methylation patterns in Arabidopsis

This study identifies CLASSY1-4 as key regulators of tissue-specific DNA methylation in Arabidopsis, showing their role in shaping epigenetic diversity during development.