Q. Jin

Increased pathogenicity and transmission of SARS-CoV-2 Omicron XBB.1.9 sublineage, including HK.3 and EG.5.1

This study investigates the virological features of SARS-CoV-2 Omicron XBB.1.9 subvariants, finding increased pathogenicity and transmissibility in HK.3 and EG.5.1 compared to previous variants.

Virological characteristics of SARS-CoV-2 Omicron BA.5.2.48

This study evaluates the virological characteristics of BA.5.2.48 subvariant isolates, finding enhanced transmission and pathogenicity compared to BA.2, with divergent features among subvariants.

Breakage fusion bridge cycles drive high oncogene copy number, but not intratumoral genetic heterogeneity or rapid cancer genome change

The paper introduces OM2BFB, an algorithm detecting BFB amplifications using OGMs, showing high precision and recall, and finds BFB events are common in certain cancers but not linked to intratumoral heterogeneity or rapid genome change.

Hormonal and transcriptomic analysis reveals the role of ABA and BR in breaking the barrier of inter-subgeneric hybridization in water lily (Nymphaea)

This study identifies ABA and BR as key regulators in overcoming inter-subgeneric hybridization barriers in water lily through transcriptomic and hormonal analyses.

Pathogen Clearance-based Correlates of Immunoprotection Reveal Insightful Features of Vaccine Immunity

This paper introduces a new vaccine evaluation system based on pathogen clearance and liver trapping to assess immunoprotective potential against bacterial infections.

Potent Bacterial Vaccines Require FcγRIIB-mediated Pathogen Capture by Liver Sinusoidal Endothelium

This paper identifies FcγRIIB-mediated capture of antibody-coated bacteria by liver sinusoidal endothelial cells as a mechanism for superior vaccine efficacy.

Cardiac patch treatment alleviates ischemic cardiomyopathy correlated with reverting Piezo1/2 expression by unloading left ventricular myocardium

This study shows cardiac patches reduce ischemic cardiomyopathy by lowering mechanical load and reverting Piezo1/2 expression in the left ventricle.

A dual mechanism of APC/C inhibition by MAP kinases

This study identifies two MAPK pathways that inhibit APC/C activity during mitotic arrest in fission yeast, clarifying their role in spindle checkpoint activation and chromosome segregation.

GJA1-20k, an internally translated isoform of Connexin 43, is an actin capping protein

This study identifies GJA1-20k as an actin capping protein that regulates mitochondrial fission and protects against ischemia-reperfusion injury.

Identification of Six Thiolases and their Effects on Fatty Acid and Ergosterol Biosynthesis in Aspergillus oryzae

This study identifies six thiolases in Aspergillus oryzae and shows their roles in fatty acid and ergosterol biosynthesis, with some exhibiting dual functionality.

Controls on the isotopic composition of microbial methane

The paper develops a biochemical-isotopic model of methanogenesis to predict isotopic signatures and shows they constrain in-situ energetics.

Structure-Function in Helical Cardiac Musculature Using Additive Textile Manufacturing

This study uses additive textile manufacturing to create helically aligned cardiac muscle models, showing improved mechanical function compared to circumferential models.

Changes and composition of microbial community during aerobic composting of household food waste

This study compares microbial communities in natural and bacteria-added composting of household food waste, finding that different dominant bacteria influence degradation rates and odor removal.

Estimating Ectopic Beat Probability with Simplified Statistical Models that Account for Experimental Uncertainty

The paper develops a simplified logistic regression model to estimate ectopic beat probability from cardiac myocyte parameters and demonstrates how experimental uncertainties affect this probability.

The Rhinolophus affinis bat ACE2 and multiple animal orthologs are functional receptors for bat coronavirus RaTG13 and SARS-CoV-2

This study identifies RaACE2 as a functional receptor for SARS-CoV-2 and RaTG13, and evaluates ACE2s from 16 species for their ability to mediate virus entry.

Single-cell RNA-sequencing of peripheral neuroblastic tumors reveals an aggressive transitional cell state at the junction of an adrenergic-mesenchymal transdifferentiation trajectory

This study uses single-cell RNA-sequencing to identify a transitional cell state in peripheral neuroblastic tumors associated with poor prognosis and therapeutic targets.

Humanized Single Domain Antibodies Neutralize SARS-CoV-2 by Targeting Spike Receptor Binding Domain

This study identifies humanized single domain antibodies that neutralize SARS-CoV-2 by targeting the spike receptor binding domain, showing improved activity when fused with the Fc region.

Estimating the Probability of Early Afterdepolarization and Predicting Arrhythmic Risk associated with Long QT Syndrome Type 1 Mutations

The paper develops a logistic regression model to estimate early afterdepolarization probability for LQTS1 mutations and compares it with two other risk metrics, finding similar performance but incomplete functional understanding of mutations.

The Pathogenicity of SARS-CoV-2 in hACE2 Transgenic Mice

This study infects hACE2 transgenic mice with SARS-CoV-2 and observes pathogenic effects, confirming Koch's postulates and establishing a model for vaccine and therapeutic development.

An engineered serum albumin-binding AAV9 capsid achieves improved liver transduction after intravenous delivery in mice

This study engineers an AAV9 capsid to bind serum albumin, improving liver transduction in mice after intravenous delivery.

Nitric oxide synthase-mediated early nitric oxide-burst alleviates drought-induced oxidative damage in ammonium supplied-rice roots

This study shows that an early nitric oxide burst mediated by nitric oxide synthase in ammonium-supplied rice roots reduces drought-induced oxidative damage by enhancing antioxidant defenses.

USP7 cooperates with NOTCH1 to drive the oncogenic transcriptionalprogram in T cell leukemia

This study identifies USP7 as a key driver of T-cell leukemia by stabilizing NOTCH1 and JMJD3, showing USP7 inhibition blocks leukemia growth and suggests it as a therapeutic target.