Bimodular Architecture of Bacterial Effector SAP05 Drives Ubiquitin-Independent Targeted Protein Degradation
Q. Liu, A. Maqbool, F. G. Mirkin, Y. Singh, C. E. Stevenson, D. M. Lawson, S. Kamoun, W. Huang, S. A. Hogenhout
This paper reports the crystal structures of SAP05 complexes and reveals their bimodular architecture enabling ubiquitin-independent targeted protein degradation in eukaryotic cells.
bioRxiv · Jun 19, 2023Biochemistry