T. B. K. Le

The paper investigates how GafY and GafZ regulate the CcGTA gene cluster in Caulobacter crescentus through transcriptional activation and anti-termination mechanisms.

This study investigates the cell cycle-dependent regulation of the ParABS system in Bdellovibrio bacteriovorus, revealing how ParA:ParB ratios and chromosomal context influence centromere organization during its unique non-binary division.

This study investigates how C8-linked PBD bi-aryl monomers cause DNA damage in Caulobacter crescentus and identifies the repair mechanisms required for survival.

The paper solves the structure of a truncated Bacillus subtilis Noc protein bound to NBS DNA, revealing disengagement between its CTP-binding and DNA-binding domains.

This study identifies a CTP-dependent gating mechanism in ParB that regulates its nucleation, spreading, and recycling during chromosome segregation in Caulobacter crescentus.

This study shows that CTP regulates the membrane-binding activity of the nucleoid occlusion protein Noc in Bacillus subtilis by controlling its ability to form nucleoprotein complexes.

The paper describes the chemical synthesis and purification of CTPγS, a non-hydrolyzable analog of CTP, to study CTPase enzymes.

This study shows that during sporulation in Streptomyces venezuelae, chromosome arms transition from spatial separation to close alignment, mediated by ParB, SMC, and HupS.

This study investigates how DNA-binding specificity diversifies in ParB and Noc proteins by identifying key residues and mutational paths that reprogram specificity.

This study shows that cytidine triphosphate (CTP) is required for ParB spreading on DNA in vitro, using purified proteins from Caulobacter crescentus.

The paper identifies additional parS sites and characterizes ParB's genomic distribution in Caulobacter crescentus, showing its role in chromosome segregation.

This study shows that SMC aligns chromosomal arms in Caulobacter crescentus via ParB and that convergent transcription disrupts this alignment.