Donor Macrophages Modulate Rejection after Heart Transplantation
B. Kopecky, H. Dun, J. Amrute, C.-Y. Lin, A. Bredemeyer, Y. Terada, P. Bayguinov, A. Koenig, C. Frye, J. Fitzpatrick, D. Kreisel, K. Lavine
This study identifies donor CCR2+ macrophages as key drivers of heart transplant rejection and shows that inhibiting MYD88 signaling in these cells extends graft survival.
bioRxiv · Sep 17, 2021Immunology