This study reveals that homodecameric Rad52 facilitates single-position Rad51 nucleation in homologous recombination through specific structural and interaction features.

bioRxiv · Feb 5, 2023 · PreprintBiochemistry

Donor Macrophages Modulate Rejection after Heart Transplantation

B. Kopecky, H. Dun, J. Amrute, C.-Y. Lin, A. Bredemeyer, Y. Terada, P. Bayguinov, A. Koenig, C. Frye, J. Fitzpatrick, D. Kreisel, K. Lavine

This study identifies donor CCR2+ macrophages as key drivers of heart transplant rejection and shows that inhibiting MYD88 signaling in these cells extends graft survival.

bioRxiv · Sep 17, 2021Immunology

Integrated plasma proteomic and single-cell immune signaling network signatures demarcate mild, moderate, and severe COVID-19

D. Feyaerts, J. Hedou, J. Gillard, H. Chen, E. S. Tsai, L. S. Peterson, K. Ando, M. Manohar, E. Do, G. K. R. Dhondalay, J. Fitzpatrick, M. Artandi, I. Chang, T. T. Snow, R. S. Chinthrajah, , D. R. McIlwain

This study integrates plasma proteomics and single-cell immune features to classify COVID-19 severity and identify biological signatures of disease progression.

bioRxiv · Feb 9, 2021Immunology

Cryo-EM structure of a proton-activated chloride channel TMEM206

Z. Deng, Y. Zhao, J. Feng, J. Zhang, H. Zhao, M. J. Rau, J. Fitzpatrick, H. Hu, P. Yuan

The paper reports the cryo-EM structure of pufferfish TMEM206, revealing its trimeric architecture and chloride ion selectivity, and compares it to sodium channels despite sequence differences.

bioRxiv · Nov 5, 2020Biophysics

Staphylococcus aureus infects osteoclasts and replicates intracellularly

P. Roper, J. Krauss, A. Ballard, C.-C. Shih, J. Fitzpatrick, J. Cassat, P. Y. Ng, N. Pavlos, D. Veis

This study shows Staphylococcus aureus can infect and replicate within osteoclasts, contributing to osteomyelitis progression by evading immune clearance.

bioRxiv · May 14, 2019Cell Biology