Author

D. Kreisel

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 7 Cell Biology· 2 Physiology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 8 Research Focus:cell type annotation· 6 Approach:experimental assay· 6 Approach:statistical model· 5 Research Focus:cell-cell communication· 4 Research Focus:differential expression· 4 Research Focus:host-pathogen & immune response· 4 Assay:scRNA-seq· 4

Frequent Co-Authors

H. Dun· 4 shared W. Li· 4 shared Y. Liu· 4 shared A. Bredemeyer· 3 shared A. E. Gelman· 3 shared B. Kopecky· 3 shared B. W. Wong· 3 shared G. S. Heo· 3 shared

Activity by Year

2020-2024 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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4 shared papersImmunology

H. Dun

Mutual co-authors in cluster

Author profile →

10 papers

Recent·Most cited

Acute kidney injury triggers hypoxemia by inducing intravascular neutrophil retention that reduces lung capillary blood flow

Y. Komaru, L. Ning, C. Lama, A. Suresh, E. Kefaloyianni, M. J. Miller, S. Kawana, H. M. Shepherd, W. Li, D. Kreisel, A. Herrlich

This study identifies that acute kidney injury causes hypoxemia through intravascular neutrophil retention in lung capillaries, reducing blood flow without lung edema.

bioRxiv · Feb 27, 2024Physiology

Targeting the Immune-Fibrosis Axis in Myocardial Infarction and Heart Failure

J. M. Amrute, X. Luo, V. Penna, A. Bredemeyer, T. Yamawaki, G. S. Heo, S. Shi, A. L. Koenig, S. Yang, F. F. Kadyrov, C. Jones, C. Kuppe, B. Kopecky, S. Hayat, P. Ma, , K. Lavine

The paper identifies a fibroblast trajectory associated with cardiac fibrosis and shows that macrophage-fibroblast crosstalk via IL-1β signaling drives fibrosis.

bioRxiv · Oct 17, 2022 · PreprintImmunology

Hypoxia Sensing in Resident Cardiac Macrophages Regulates Monocyte Fate Specification following Ischemic Heart Injury

F. F. Kadyrov, A. L. Koenig, J. M. Amrute, H. Dun, W. Li, C. J. Weinheimer, J. M. Nigro, A. Kovacs, A. L. Bredemeyer, L. Lai, B. J. Kopecky, V. Penna, D. Kreisel, K. J. Lavine

This study shows that hypoxia sensing in cardiac macrophages influences monocyte differentiation into inflammatory states after heart injury.

bioRxiv · Aug 4, 2022 · PreprintImmunology

Targeting fatty acid beta-oxidation impairs monocyte differentiation and prolongs heart allograft survival

Y. Zhu, H. Dun, L. Ye, Y. Terada, L. Shriver, G. J. Patti, D. Kreisel, A. E. Gelman, B. W. Wong

This study shows that inhibiting fatty acid beta-oxidation impairs monocyte differentiation and improves heart allograft survival by reducing immune cell infiltration.

bioRxiv · Feb 9, 2022Immunology

Reprogramming Alveolar Macrophage Responses to TGF-β Reveals CCR2+ Monocyte Activity that Promotes Bronchiolitis Obliterans Syndrome

Z. Liu, F. Liao, J. Zhu, D. Zhou, G. S. Heo, H. P. Luehmann, D. Scozzi, A. Parks, R. Hachem, D. Byers, L. K. Tague, H. S. Kulkarni, M. Cano, B. W. Wong, W. Li, , A. E. Gelman

This study identifies alveolar macrophage reprogramming by ECP that reduces TGF-β bioavailability and prevents BOS by inhibiting CCR2+ monocyte-driven inflammation.

bioRxiv · Jan 27, 2022 · PreprintImmunology

Donor Macrophages Modulate Rejection after Heart Transplantation

B. Kopecky, H. Dun, J. Amrute, C.-Y. Lin, A. Bredemeyer, Y. Terada, P. Bayguinov, A. Koenig, C. Frye, J. Fitzpatrick, D. Kreisel, K. Lavine

This study identifies donor CCR2+ macrophages as key drivers of heart transplant rejection and shows that inhibiting MYD88 signaling in these cells extends graft survival.

bioRxiv · Sep 17, 2021Immunology

Circulating osteopontin released by injured kidneys causes pulmonary inflammation and edema

F. Z. Khamissi, L. Ning, E. Kefaloyianni, H. Dun, A. Arthanarisami, A. Keller, J. J. Atkinson, W. Li, B. W. Wong, S. Dietmann, K. Lavine, D. Kreisel, A. Herrlich

This study identifies osteopontin (OPN) released by injured kidneys as a mediator of acute lung injury, showing its role in causing pulmonary inflammation and edema.

bioRxiv · Jul 20, 2021 · PreprintCell Biology

Resident Cardiac Macrophages Mediate Adaptive Myocardial Remodeling

N. R. Wong, J. Mohan, B. Kopecky, S. Guo, L. Du, J. Leid, O. Dmytrenko, H. Luehmann, G. Bajpai, L. Ewald, L. Bell, N. Patel, I. Lokshina, A. Bredemeyer, C. J. Weinheimer, , K. J. Lavine

This study identifies CCR2- resident cardiac macrophages as critical for adaptive myocardial remodeling in heart failure, showing their role in ventricular remodeling and coronary angiogenesis.

bioRxiv · Jan 28, 2021Immunology

Circulating Mitochondrial DNA is an Early Indicator of Severe Illness and Mortality from COVID-19

D. Scozzi, M. Cano, L. MA, D. Zhou, J. H. Zhu, J. A. O'Halloran, C. Goss, A. Rauseo, Z. Liu, V. Peritore, M. Rocco, A. Ricci, R. Amodeo, L. Aimati, M. Ibrahim, , A. E. Gelman

This study shows that high levels of circulating mitochondrial DNA predict severe illness and mortality in COVID-19 patients.

bioRxiv · Jul 30, 2020Immunology

Chemokine receptor 2-targeted molecular imaging in pulmonary fibrosis

S. L. Brody, S. P. Gunsten, H. P. Luehmann, D. H. Sultan, M. Hoelscher, G. S. Heo, J. Pan, J. R. Koenitzer, E. C. Lee, T. Huang, C. Mpoy, S. Guo, R. Laforest, A. Salter, T. D. Russell, , Y. Liu

PET imaging of CCR2+ cells in lung fibrosis identifies therapeutic response in mouse models and shows perifibrotic signal in IPF patients.

bioRxiv · Mar 4, 2020Cell Biology