Author

A. Bredemeyer

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 4 Assay:scRNA-seq· 4 Research Focus:cell-cell communication· 3 Approach:experimental assay· 3 Organism:mouse· 3 Approach:deep learning· 2 Research Focus:differential expression· 2 Organism:human· 2

Frequent Co-Authors

K. Lavine· 4 shared B. Kopecky· 3 shared D. Kreisel· 3 shared Y. Liu· 3 shared C.-Y. Lin· 2 shared G. Bajpai· 2 shared G. Feng· 2 shared G. S. Heo· 2 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersImmunology

K. Lavine

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Differential chromatin accessibility and transcriptional dynamics define breast cancer subtypes and their lineages

M. D. Iglesia, R. G. Jayasinghe, S. Chen, N. V. Terekhanova, J. M. Herndon, E. Storrs, A. Karpova, D. C. Zhou, N. Naser Al Deen, A. T. Shinkle, R. J.-H. Lu, W. Caravan, A. Houston, Y. Zhao, K. Sato, , Marge

This study identifies breast cancer subtypes and their lineage origins by analyzing chromatin accessibility and transcriptional dynamics using multi-omic techniques.

bioRxiv · Oct 31, 2023Cancer Biology

Expansion of Disease Specific Cardiac Macrophages in Immune Checkpoint Inhibitor Myocarditis

P. Ma, J. Liu, J. Qin, L. Lai, G. S. Heo, H. Luehmann, D. Sultan, A. Bredemeyer, G. Bajpai, G. Feng, J. Jimenez, A. Parks, J. Amrute, A. Villanueva, Y. Liu, , K. Lavine

This study identifies an inflammatory macrophage population expanded in ICI myocarditis, driven by IFN-γ signaling and T-cell interactions, suggesting IFN-γ blockade as a potential therapeutic strategy.

bioRxiv · Apr 28, 2023 · PreprintImmunology

Targeting the Immune-Fibrosis Axis in Myocardial Infarction and Heart Failure

J. M. Amrute, X. Luo, V. Penna, A. Bredemeyer, T. Yamawaki, G. S. Heo, S. Shi, A. L. Koenig, S. Yang, F. F. Kadyrov, C. Jones, C. Kuppe, B. Kopecky, S. Hayat, P. Ma, , K. Lavine

The paper identifies a fibroblast trajectory associated with cardiac fibrosis and shows that macrophage-fibroblast crosstalk via IL-1β signaling drives fibrosis.

bioRxiv · Oct 17, 2022 · PreprintImmunology

Donor Macrophages Modulate Rejection after Heart Transplantation

B. Kopecky, H. Dun, J. Amrute, C.-Y. Lin, A. Bredemeyer, Y. Terada, P. Bayguinov, A. Koenig, C. Frye, J. Fitzpatrick, D. Kreisel, K. Lavine

This study identifies donor CCR2+ macrophages as key drivers of heart transplant rejection and shows that inhibiting MYD88 signaling in these cells extends graft survival.

bioRxiv · Sep 17, 2021Immunology

Resident Cardiac Macrophages Mediate Adaptive Myocardial Remodeling

N. R. Wong, J. Mohan, B. Kopecky, S. Guo, L. Du, J. Leid, O. Dmytrenko, H. Luehmann, G. Bajpai, L. Ewald, L. Bell, N. Patel, I. Lokshina, A. Bredemeyer, C. J. Weinheimer, , K. J. Lavine

This study identifies CCR2- resident cardiac macrophages as critical for adaptive myocardial remodeling in heart failure, showing their role in ventricular remodeling and coronary angiogenesis.

bioRxiv · Jan 28, 2021Immunology