C. G. Pearson

Poc1 is a basal body inner junction protein that promotes triplet microtubule integrity and interconnections

This study identifies Poc1 as a basal body protein that stabilizes triplet microtubules and interconnections, enhancing resistance to ciliary forces.

Label-free proteomic comparison reveals ciliary and non- ciliary phenotypes of IFT-A mutants

The paper applies DIFFRAC to study proteomic changes in Ift122 mutants of Tetrahymena thermophila, revealing both ciliary and non-ciliary effects of IFT-A loss.

Intracellular connections between basal bodies promote the coordinated behavior of motile cilia

The paper shows that intracellular connections between basal bodies control ciliary waveform and coordination in Tetrahymena thermophila, enhancing fluid flow.

Trisomy 21 induces pericentrosomal crowding disrupting early stages of primary ciliogenesis and mouse cerebellar development

This study shows that trisomy 21 causes pericentrosomal crowding, disrupting ciliogenesis and leading to neurological deficits in mice.

Trisomy 21 increases microtubules and disrupts centriolar satellite localization

This study shows that increased Pericentrin in trisomy 21 disrupts microtubule networks and mislocalizes centriolar satellites, impairing primary cilia formation.

Plastic cell morphology changes during dispersal

The paper investigates morphological plasticity in dispersal strategies among Tetrahymena thermophila strains, finding that multiple plastic morphological changes influence cilia-dependent motility during dispersal.

A semi-automated machine learning-aided approach to quantitative analysis of centrosomes and microtubule organization

This paper develops a semi-automated machine learning tool to analyze centrosome and microtubule organization in breast cancer cells, finding that supernumerary centrosomes increase PCM size and MT density.

Microtubule glycylation promotes basal body attachment to the cell cortex

This study identifies tubulin glycylation as essential for basal body microtubule attachment to the cell cortex, which is critical for ciliary array organization.