M. Joshi

Unravelling Genomic Origin of Lumpy Skin Disease Virus in Recent Outbreaks

This study uses whole genome sequencing to analyze genetic variations in Lumpy Skin Disease Virus (LSDV) from 2022 outbreaks, identifying key mutations and phylogenetic clusters linked to pathogenesis.

Penetration of Topically Applied Polymeric Nanoparticles across the Epidermis of Thick skin

This study compares tape-stripping and microneedle abrasion for disrupting thick skin's stratum corneum to enhance nanoparticle penetration.

Patterns of speciation in a parapatric pair of Saturnia moths as revealed by Target Capture

This study uses target capture and mtDNA sequencing to resolve the phylogenetic relationships and taxonomy of two parapatric Saturnia moth species, revealing mitonuclear discordance and past introgression.

Species Delimitation Under Allopatry: Genomic Divergences Within and Across Continents in Lepidoptera

This study examines genomic divergence in allopatric lepidopteran species across continents, finding that DNA barcodes often align with nuclear markers but highlight the need for universal genetic loci to improve species delimitation.

RNASeq as a tool to understand dysregulation of potential biomarkers in HNSC

The paper uses RNASeq to identify differentially expressed genes in oral cancer, analyzes their functional enrichment, and identifies hub genes as potential biomarkers for margin clearance.

Role of Rab5 early endosomes in regulating Drosophila gut antibacterial response

This study shows that Rab5 early endosomes regulate Drosophila gut antibacterial response by influencing NF-κB gene expression through PGRP-LE aggregation.

Delimiting Continuity: Comparison of Target Enrichment and ddRAD for Delineating Admixing Parapatric Melitaea Butterflies

This study compares target enrichment and ddRAD sequencing in parapatric Melitaea butterflies, finding congruent phylogenetic results and recommending consistent classification of parapatric taxa.

Trisomy 21 increases microtubules and disrupts centriolar satellite localization

This study shows that increased Pericentrin in trisomy 21 disrupts microtubule networks and mislocalizes centriolar satellites, impairing primary cilia formation.

Transcriptional control of DNA repair networks by CDK7 regulates sensitivity to radiation in Myc-driven Medulloblastoma

This study identifies CDK7 as a therapeutic target in Myc-driven medulloblastoma, showing that its inhibition sensitizes tumors to radiation.

NPEPPS is a novel and druggable driver of platinum resistance

This study identifies NPEPPS as a driver of cisplatin resistance in bladder cancer and shows its inhibition can enhance cisplatin efficacy in preclinical models.

Conformational plasticity and dynamic interactions of the N-terminal domain of the chemokine receptor CXCR1

This paper investigates the conformational dynamics of the N-terminal domain of CXCR1 during ligand binding using simulations and NMR validation, showing ligand-induced conformational changes.

HERC1 regulates breast cancer cells migration and invasion

This study identifies HERC1 as a regulator of breast cancer cell migration and invasion, showing its potential as a therapeutic target.

USP19 modulates cancer cell migration and invasion and acts as a novel prognostic marker in patients with early breast cancer

This study identifies USP19 as a regulator of cancer cell migration and invasion, showing its role as a prognostic marker in early breast cancer.

Identification of unique mutations in SARS-CoV-2 strains isolated from India suggests its attenuated pathotype

The paper identifies unique mutations in SARS-CoV-2 strains from India, suggesting an attenuated pathotype with implications for vaccine development.

Trisomy 21 activates the kynurenine pathway via increased dosage of interferon receptors

This study identifies a mechanism by which Trisomy 21 increases kynurenine pathway activity through overexpression of interferon receptors, leading to immunosuppression and neurotoxicity in Down syndrome.