K. Narayan

Evaluating HIV Infectivity and Virion Maturation Across Varied Producer Cells with a Novel FRET-Based Detection and Quantification Assay

This study compares HIV-1 virion maturation and infectivity between Jurkat and HEK293T cells using a FRET-based assay, finding lower maturation and infectivity in Jurkat-derived virions.

Spatial and Temporal Coordination of Force-generating Actin-based Modules Drives Membrane Remodeling In Vivo

The paper shows how actin filaments dynamically adjust their structure to control membrane transfer between cellular compartments in live rodents.

A spatial map of hepatic mitochondria uncovers functional heterogeneity shaped by nutrient-sensing signaling

The paper investigates mitochondrial heterogeneity in the liver by combining spatial proteomics and functional analysis, revealing distinct metabolic functions in periportal and pericentral regions.

Conserved cysteine residues in Kaposi's sarcoma herpesvirus ORF34 are necessary for viral production and viral pre-initiation complex formation.

This study identifies four conserved cysteine residues in KSHV ORF34 essential for vPIC formation and viral production through alanine-scanning mutants and structural modeling.

Intracellular connections between basal bodies promote the coordinated behavior of motile cilia

The paper shows that intracellular connections between basal bodies control ciliary waveform and coordination in Tetrahymena thermophila, enhancing fluid flow.

Instance segmentation of mitochondria in electron microscopy images with a generalist deep learning model.

The paper develops a deep learning model for mitochondria instance segmentation in EM images and releases a tool for inference and visualization.

Endosomes deliver ceramide phosphoethanolamine with unique acyl chain anchors to the cleavage furrow during male meiotic cytokinesis

The paper was withdrawn due to duplicate posting, and the correct version is available at the provided URL.

Multivalent Interactions between Molecular Components Involved in Fast Endophilin Mediated Endocytosis Drive Protein Phase Separation

The paper shows how multivalent interactions between endophilin, LPD, and TIL drive protein phase separation during FEME.

Universal protein misfolding intermediates can bypass the proteostasis network and remain soluble and less-functional

The paper shows that misfolded proteins can bypass proteostasis by being structurally similar to native states and persisting for long periods.

Endosomes deliver ceramide phosphoethanolamine with unique acyl chain anchors to the cleavage furrow during male meiotic cytokinesis

This study identifies Ceramide phosphoethanolamine (CPE) and its delivery via Rab7-positive endosomes as essential for male meiotic cytokinesis.

CEM500K - A large-scale heterogeneous unlabeled cellular electron microscopy image dataset for deep learning.

The paper introduces CEM500K, a large-scale unlabeled EM dataset for deep learning, showing pre-trained models achieve state-of-the-art results on segmentation tasks.

HIV corruption of the Arp2/3-Cdc42-IQGAP1 axis to hijack cortical F-Actin to promote cell-cell viral spread.

The paper identifies HIV's manipulation of the Arp2/3-Cdc42-IQGAP1 pathway to hijack cortical F-Actin for cell-cell viral spread, showing that this process prevents particle release but enables infection through maturation of contacts.