Author

C. Gelot

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:chromatin & epigenetic regulation· 2 Assay:DNA methylation· 2 Approach:biophysical modeling· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

R. Ceccaldi· 2 shared A. A. Ishchenko· 1 shared A. Barascu· 1 shared A. D. D'Andrea· 1 shared A. Farkkila· 1 shared A. Li· 1 shared A. Syed· 1 shared B. Kochupurakkal· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersCell Biology

R. Ceccaldi

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Polθ is phosphorylated by Polo-like kinase 1 (PLK1) to enable repair of DNA double strand breaks in mitosis

C. Gelot, M. T. Kovacs, S. Miron, E. Mylne, R. Ghouil, T. Popova, F. Dingli, D. Loew, J. Guirouilh-Barbat, E. Del Nery, S. Zinn-Justin, R. Ceccaldi

This study identifies Polθ as a key factor in repairing DNA double strand breaks during mitosis, showing that its phosphorylation by PLK1 enables this process and maintains genome integrity.

bioRxiv · Mar 17, 2023Cell Biology

Polymerase Theta Inhibition Kills Homologous Recombination Deficient Tumors

J. Zhou, C. Gelot, C. Pantelidou, A. Li, H. Yucel, R. E. Davis, A. Farkkila, B. Kochupurakkal, A. Syed, G. I. Shapiro, J. A. Tainer, B. S. Blagg, R. Ceccaldi, A. D. D'Andrea

The paper identifies Novobiocin as a POLθ inhibitor that selectively kills HR-deficient tumors, including those resistant to PARP inhibitors.

bioRxiv · May 23, 2020Cancer Biology

An adaptive pre-DNA-damage-response protects genome integrity

S. Ragu, G. Matos-Rodrigues, N. Droin, A. Barascu, S. Caillat, G. Zarkovic, C. Siberchicot, E. Dardillac, C. Gelot, J. P. Radicella, A. A. Ishchenko, J.-L. Ravanat, E. Solary, B. S. Lopez

The paper identifies a pre-DDR response in human fibroblasts that protects genome integrity without arresting cell cycle progression by managing ROS levels below a stress threshold.

bioRxiv · May 13, 2020 · PreprintCell Biology