Cell BiologybioRxiv
Polθ is phosphorylated by Polo-like kinase 1 (PLK1) to enable repair of DNA double strand breaks in mitosis
C. Gelot, M. T. Kovacs, S. Miron…·R. Ceccaldi
This study identifies Polθ as a key factor in repairing DNA double strand breaks during mitosis, showing that its phosphorylation by PLK1 enables this process and maintains genome integrity.
DOI 10.1038/s41586-023-06506-6