Induction of transposable element expression is central to innate sensing
D. C. Rookhuizen, P.-E. Bonte, M. Ye, T. Hoyler, M. Gentili, N. Burgdorf, S. Durand, F. Apprahamian, G. Kroemer, N. Manel, J. Waterfall, R. Milne, C. Goudot, G. J. Towers, S. Amigorena
The paper shows that exogenous PAMPs epigenetically activate LINE1 TEs, which engage cGAS to enhance innate immune responses.
bioRxiv · Sep 10, 2021 · PreprintImmunology