M. Ye

A Ctnnb1 enhancer transcriptionally regulates Wnt signaling dosage to balance homeostasis and tumorigenesis of intestinal epithelia

This study identifies an enhancer of Ctnnb1 that regulates Wnt signaling dosage, maintaining intestinal homeostasis and suppressing colorectal cancer.

SON-dependent nuclear speckle rejuvenation alleviates proteinopathies

This study identifies pyrvinium pamoate as a compound that rejuvenates nuclear speckles, improving protein quality control and reducing YAP1 activity, thereby alleviating proteinopathies in pre-clinical models.

CLSTN3B enhances adipocyte lipid droplet structure and function via endoplasmic reticulum contact

This study identifies CLSTN3B as a key protein for adipocyte lipid droplet maturation by facilitating ER-LD contacts, enhancing lipid storage and metabolic health.

A peptide-centric local stability assay to unveil protein targets of diverse ligands

This paper introduces PELSA, a peptide-centric local stability assay that identifies ligand-binding regions across the proteome with high sensitivity and without ligand modification.

Superiority of intranasal over systemic administration of bioengineered soluble ACE2 for survival and brain protection against SARS-CoV-2 infection

This study compares intranasal and systemic administration of bioengineered soluble ACE2 in mice, finding intranasal delivery provides better survival and brain protection against SARS-CoV-2.

Gluebodies improve crystal reliability and diversity through transferable nanobody mutations that introduce constitutive close contacts

The paper engineers nanobody interfaces to improve crystal reliability and diversity, resulting in better diffraction and multiple polymorphs.

PRMT1 regulates EGFR and Wnt signaling pathways and is a promising target for combinatorial treatment of breast cancer

This study identifies PRMT1 as a key regulator of EGFR and Wnt signaling in breast cancer and shows that targeting it with inhibitors can enhance chemotherapy and EGFR inhibitor efficacy in TNBC.

Induction of transposable element expression is central to innate sensing

The paper shows that exogenous PAMPs epigenetically activate LINE1 TEs, which engage cGAS to enhance innate immune responses.

Development of a Novel PROTAC using the Nucleic Acid Aptamer as a Targeting Ligand for Tumor Selective Degradation of Nucleolin

This paper develops a novel PROTAC, ZL216, using an aptamer as a targeting ligand to selectively degrade nucleolin in breast cancer cells, inhibiting their proliferation and migration.

Reduced virulence and enhanced host adaption during antibiotics therapy: A story of a within-host carbapenem-resistant Klebsiella pneumoniae sequence type 11 evolution in a fatal scrotal abscess patient

This study tracks the genomic evolution of ST11-CRKP during antibiotic therapy in a patient, identifying mutations linked to reduced virulence and increased host adaptation.

Case study of a rhizosphere microbiome assay on a bamboo rhizome with excessive shoots

The paper studies a rare bamboo rhizome phenomenon with excessive shoots, analyzing its associated microbiome and finding correlations between bacterial genera and shoot numbers.

Data-informed discovery of hydrolytic nanozymes

This paper develops data-informed strategies to design hydrolytic nanozymes with enhanced catalytic activity and broad substrate specificity.

Human fecal microbiota is associated with colorectal cancer

This study analyzes fecal microbiota composition in CRC patients and identifies Fusobacterium as a potential biomarker for CRC screening in Chinese populations.

Proteomics study of colorectal cancer and adenomatous polyps identifies TFR1, SAHH, and HV307 as potential biomarkers for screening

This study identifies TFR1, SAHH, and HV307 as potential biomarkers for colorectal cancer screening through proteomics analysis of pre-cancerous to cancerous tissues.

Kidney and Lung ACE2 expression after an ACE inhibitor or an Ang II receptor blocker: implications for COVID-19

This study examines how ACE inhibitors and Ang II receptor blockers affect ACE2 expression in kidney and lung tissues, finding no significant increase that would suggest a risk for SARS-CoV-2 infection.

Tissue-specific volatile-mediated defense regulation in maize leaves and roots

This study investigates whether maize roots respond to herbivore-induced plant volatiles (HIPVs) like leaves, finding no significant changes in root traits or herbivore resistance.

The Low-Cost, Semi-Automated Shifter Microscope Stage Transforms Speed and Robustness of Manual Protein Crystal Harvesting

The Shifter microscope stage automates parts of protein crystal harvesting, increasing mounting rates and reducing manual effort while maintaining diffraction quality.

Frequency of mutations in 21 hereditary breast and ovarian cancer susceptibility genes among high-risk Chinese individuals

The paper assesses the frequency of deleterious mutations in 21 hereditary breast and ovarian cancer genes among 882 high-risk Chinese individuals, finding 19.5% carried such mutations, with higher rates in those with both breast and ovarian cancer histories.

Strategies to improve scFvs as crystallization chaperones suggested by analysis of a complex with the human PHD-bromodomain SP140

The paper uses a scFv to solve the structure of SP140's PHD-bromodomain and suggests strategies to improve scFvs as crystallization chaperones.

Clinical Efficacy and Adverse Effects of Antibiotics Used to Treat Mycobacterium abscessus Pulmonary Disease

This study evaluates the efficacy and adverse effects of antibiotics in treating M. abscessus pulmonary disease, finding that four antibiotics correlate with treatment success but are associated with severe side effects.

Molecular dissection of early defense signaling underlying volatile-mediated defense priming and herbivore resistance in rice

This study shows that indole, a volatile compound, primes early defense signaling in rice, enhancing resistance to herbivores by upregulating key signaling components like OsMPK3 and OsWRKY70.

Can herbivore-induced volatiles protect plants by increasing the herbivores’ susceptibility to natural pathogens?

The paper tests if herbivore-induced plant volatiles (HIPVs) increase herbivore susceptibility to pathogens, finding that indole enhances susceptibility to viruses and bacteria.

Deubiquitylation and stabilization of p21 by USP11 is critical for cell cycle progression and DNA damage responses

This study identifies USP11 as a deubiquitylase that stabilizes p21, affecting cell cycle progression and DNA damage responses.

An inducible CRISPR-ON system for controllable gene activation in human pluripotent stem cells

This paper develops an inducible CRISPR-ON system to controllably activate genes in human pluripotent stem cells, demonstrating its ability to regulate NANOG expression and enhance cell survival and integration with mouse blastocysts.