Epigenetic control of CD8+ T cell tissue homing and tissue resident memory T cell precursors by the histone methyltransferase SUV39H1
G. Suarez, S. Heurtebise-Chretien, P.-E. Bonte, H. Beuchet, J. Fuentealba, C. Goudot, O. Lantz, S. Amigorena
This study shows that SUV39H1 depletion in CD8+ T cells enhances tissue homing and TRM differentiation, improving therapeutic outcomes in infection and cancer.
bioRxiv · May 13, 2024 · PreprintImmunology