C. H. Ihling

This study uses mass spectrometry and computational modeling to assess the structure of full-length wild-type p53, revealing compaction of the C-terminal region and supporting a model of DNA binding.

The paper identifies an AML-specific conformation of Integrin-β2 using structural surfaceomics and demonstrates its targeting by CAR-T cells.

This study observes elongated conformational states of α-synuclein during liquid-liquid phase separation using XL-MS and COMPASS, providing insights into early stages of Parkinson's Disease.

This paper demonstrates the use of XL-MS combined with ion mobility on a timsTOF Pro instrument to study protein conformations and interactions, identifying numerous cross-links and interactions in different protein systems.

The paper presents the first 3D-structural analysis of active, full-length ROS-GC1 in bovine retina using XL-MS and computational modeling, revealing a novel domain organization and dimeric architecture.

This study uses XL-MS to analyze E. coli ribosome structures, revealing conformational plasticity and remodeling 2,057 residues with high accuracy.

The paper investigates how flexible intrinsically disordered regions in AUX/IAA proteins modulate auxin receptor assemblies by positioning AUX/IAAs on TIR1 for ubiquitylation.