Author

C. Harding

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Biophysics· 1

Signature Assays, Organisms & Methods

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Organism:E. coli· 2 Approach:experimental assay· 2 Research Focus:drug response / drug discovery· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:protein structure prediction· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

J. Hall· 2 shared P. D. Aldridge· 2 shared A. Ali· 1 shared A. H. Mahadi· 1 shared A. L. Lovering· 1 shared A. M. Z. Tan· 1 shared A. Tan· 1 shared B. M. Markus· 1 shared

Activity by Year

2018-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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2 shared papersMicrobiology

J. Hall

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Exploring the in-situ evolution of Nitrofurantoin resistance in clinically derived Uropathogenic Escherichia coli isolates.

M. Vallee, C. Harding, J. Hall, P. D. Aldridge, A. Tan

This study investigates the in situ evolution of Nitrofurantoin resistance in uropathogenic E. coli isolates from two UTI patients, finding no fitness advantage for resistant strains but a selective advantage at sub-MIC concentrations.

bioRxiv · Jul 19, 2022Microbiology

Evasion of Toll-like Receptor Recognition by Escherichia coli is mediated via Population Level Regulation of Flagellin Production

M. Lanz, C. M. Birchall, L. K. Drage, D. M. Picton, C. Mowbray, Q. Alsenani, A. M. Z. Tan, A. Ali, C. Harding, R. Pickard, J. Hall, P. D. Aldridge

This study shows that uropathogenic E. coli evades TLR5 recognition by regulating flagellin production at the population level, not through antigenic variation.

bioRxiv · Nov 18, 2021 · PreprintMicrobiology

Genetic screens reveal a central role for heme biosynthesis in artemisinin susceptibility

C. Harding, S. M. Sidik, B. Petrova, N. F. Gnädig, J. Okombo, K. E. Ward, B. M. Markus, D. A. Fidock, S. Lourido

The paper uses CRISPR screens to identify genetic factors affecting artemisinin susceptibility in apicomplexan parasites, revealing heme biosynthesis as a key pathway.

bioRxiv · Aug 28, 2019Microbiology

Evidence for phospholipid export from the gram-negative inner membrane: time to rethink the Mla pathway?

G. W. Hughes, S. C. L. Hall, C. S. Laxton, P. Sridhar, A. H. Mahadi, C. Hatton, T. J. Piggot, M. Jamshad, V. Spana, I. T. Cadby, C. Harding, G. L. Isom, J. A. Bryant, R. J. Parr, Y. Yakub, , T. Knowles

The paper solves the crystal structure of MlaC and shows the Mla pathway exports phospholipids from the inner membrane to the periplasm, challenging the previous belief in retrograde transport.

bioRxiv · Aug 9, 2018 · PreprintBiophysics