The Immune-Evasive Proline 283 Substitution in Influenza Nucleoprotein Increases Aggregation Propensity Without Altering the Native Structure
J. Yoon, Y. M. Zhang, C. Her, R. A. Grant, A. M. Ponomarenko, B. E. Ackermann, G. Debelouchina, M. D. Shoulders
The paper investigates how the Pro283 substitution in influenza nucleoprotein affects protein folding and aggregation, revealing it increases aggregation propensity without altering native structure.
bioRxiv · Sep 8, 2023Biophysics