T. Iwawaki

This study shows that the IRE1α/XBP1 signaling pathway promotes myoblast fusion in skeletal muscle by upregulating profusion genes like Myomaker, crucial for muscle regeneration.

The paper shows that IRE1α is essential for CTB and CT-induced IL-1β production in tissue-resident macrophages via NLRP3 and pyrin inflammasomes.

This study shows that unconventional IRE1 activation enhances TH17 responses and neutrophilic airway inflammation in fungal asthma.

This study shows that IRE1 RNase activity in tumor-associated dendritic cells regulates antitumor immunity, with XBP1s deficiency leading to increased tumor growth and impaired T cell responses.

This study shows that the IRE1/XBP1 signaling pathway enhances skeletal muscle regeneration by boosting satellite cell proliferation in a cell non-autonomous way.

This study shows that deleting XBP1 in hepatocytes causes liver injury in mice, which is due to excessive IRE1 activation rather than XBP1 loss itself.

This study shows that IRE1 regulates macrophage polarization, PD-L1 expression, and tumor survival in mice and humans.