A. Rizuan

Structural details of helix-mediated TDP-43 C-terminal domain multimerization

This study investigates the structural basis of TDP-43 C-terminal domain multimerization using biophysical experiments, AlphaFold2-Multimer, and simulations, revealing helical oligomerization and the role of specific residues in phase separation and disease.

Intra-condensate demixing of TDP-43 inside stress granules generates pathological aggregates

This study shows that TDP-43 aggregation in stress granules requires up-concentration and oxidative stress, leading to intra-condensate demixing and pathological aggregates.

Expanding the molecular language of protein liquid-liquid phase separation

This study explores how amino acid sequences influence protein liquid-liquid phase separation and material properties of condensates through systematic sequence manipulations and molecular simulations.

Aliphatic residues contribute significantly to the phase separation of TDP-43 C-terminal domain

This study identifies aliphatic residues as critical contributors to TDP-43 C-terminal domain phase separation, expanding the molecular understanding of protein phase separation.

Molecular interactions underlying the phase separation of HP1: Role of phosphorylation, ligand and nucleic acid binding

This study investigates how phosphorylation, ligand, and nucleic acid binding influence HP1's phase separation, revealing electrostatic interactions and conformational changes in its LLPS behavior.

Zn-dependent structural transition of SOD1 modulates its ability to undergo liquid-liquid phase separation.

This study shows that Zn-dependent structural changes in SOD1 affect its ability to undergo liquid-liquid phase separation, which may contribute to ALS pathology.