Cell BiologyCell Death & DifferentiationPeer-reviewed
Hepatocyte-specific deletion of XBP1 sensitizes mice to liver injury through hyperactivation of IRE1α
C. C. Duwaerts, K. Siao, R. K. Soon…·J. J. Maher
This study shows that deleting XBP1 in hepatocytes causes liver injury in mice, which is due to excessive IRE1 activation rather than XBP1 loss itself.
DOI 10.1038/s41418-020-00671-1