Author

C. Hetz

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Animal Behavior & Cognition· 1 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Organism:mouse· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

G. Tamburini· 3 shared J. Diaz· 2 shared L. Plate· 2 shared M. Milani· 2 shared A. B. Gonzalez· 1 shared A. Blondel· 1 shared A. C. Koong· 1 shared A. Criollo· 1 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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3 shared papersCell Biology

G. Tamburini

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

BAX and BAK expression triggers multiple IRE1 signaling outputs under ER stress

C. Sepulveda, M. Milani, V. Morales, G. Tamburini, N. Montes, C. Hetz

This study shows that BAX and BAK deficiency increases ER stress threshold for XBP1 splicing and reduces RIDD substrate degradation and IRE1 phosphorylation.

bioRxiv · Mar 26, 2024 · PreprintCell Biology

The unfolded protein response transcription factor XBP1s ameliorates Alzheimer`s disease by improving synaptic function and proteostasis

C. Duran Aniotz, C. Rivera Krstulovic, N. Poblete, A. O. Ardiles, M. L. Diaz Hung, C. M. P. Sabusap, Y. Gerakis, F. Cabral Miranda, J. Diaz, M. Fuentealba, E. Munoz, S. Espinosa, G. Matinez, G. Quiroz, G. Tamburini, , C. Hetz

This study shows that overexpressing the active form of XBP1 in neurons reduces amyloid deposits and improves synaptic function in Alzheimer's disease models.

Molecular Therapy · Jul 1, 2023Peer-reviewedAnimal Behavior & Cognition

The endoplasmic reticulum stress sensor IRE1 regulates collagen secretion through the enforcement of the proteostasis factor P4HB/PDIA1 contributing to liver damage and fibrosis

Y. Hazari, H. Urra, V. A. G. Lopez, J. Diaz, G. Tamburini, M. Milani, P. Pihan, S. Durand, F. Aprahamia, R. Baxter, M. Huang, X. C. Dong, H. Vihinen, A. B. Gonzalez, P. Godoy, , C. Hetz

This study shows that IRE1 regulates collagen secretion via P4HB, contributing to liver fibrosis in models of CCl4 and high fat diet.

bioRxiv · May 2, 2023 · PreprintCell Biology

Stress-induced tyrosine phosphorylation of RtcB modulates IRE1 activity and signaling outputs.

A. Papaioannou, F. G. Centonze, A. Metais, M. Maurel, L. Negroni, M. Gonzales-Quiroz, E. Zare Golchesmeh, A. Blondel, A. C. Koong, C. Hetz, R. Pedeux, M. L. Tremblay, S. J. Mahdizadeh, G. Svensson, L. A. Eriksson, e. chevet

This study identifies RtcB tyrosine phosphorylation as a regulatory mechanism controlling IRE1's dual RNase activities, influencing cell survival or death during ER stress.

bioRxiv · Mar 2, 2020Biochemistry