Author

M. L. Tremblay

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Microbiology· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:differential expression· 3 Research Focus:host-pathogen & immune response· 3 Organism:mouse· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Organism:human· 2 Assay:metagenomics· 2

Frequent Co-Authors

A. N. Santos· 2 shared D. F. McCole· 2 shared M. R. Spalinger· 2 shared Y. Zolotarov· 2 shared A. Blondel· 1 shared A. C. Koong· 1 shared A. Diaz Quintana· 1 shared A. Hsiao· 1 shared

Activity by Year

2019-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 11 mutual co-author links

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2 shared papersMicrobiology

A. N. Santos

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

PTPN1/2 inhibition induces highly functional terminal effector CD8 T cells through autocrine IL-10

L. A. Perez-Quintero, A. Poirier, Z. Martinez-Cordoba, C.-H. Feng, I. Aubry, C. Carli, S. Kamyabiazar, A. Pacis, Y. Zolotarov, K.-A. Pike, J.-S. Delisle, M. L. Tremblay

This study shows that inhibiting PTPN1/2 enhances CD8 T cell effector function via autocrine IL-10, suggesting a new strategy for cancer immunotherapy.

bioRxiv · Apr 17, 2023 · PreprintImmunology

Identification of a Novel Susceptibility Marker for SARS-CoV-2 Infection in Human Subjects and Risk Mitigation with a Clinically Approved JAK Inhibitor in Human/Mouse Cells

M. R. Spalinger, R. Hai, J. Li, A. N. Santos, T. M. Nordgren, M. L. Tremblay, L. Eckmann, E. Hanson, M. Scharl, X. Wu, B. S. Boland, D. F. McCole

The paper identifies a genetic variant that increases SARS-CoV-2 receptor expression and susceptibility, and shows a JAK inhibitor reduces this risk.

bioRxiv · Dec 9, 2020 · PreprintMicrobiology

ARL15 modulates magnesium homeostasis through N-glycosylation of CNNMs

Y. Zolotarov, C. Ma, I. Gonzalez-Recio, S. Hardy, G. Franken, N. Uetani, F. Latta, E. Kostantin, J. Boulais, M.-P. Thibault, J.-F. Cote, I. Diaz Moreno, A. Diaz Quintana, J. G. J. Hoenderop, L. A. Martinez-Cruz, , J. H. F. de Baaij

This study identifies ARL15 as a regulator of magnesium homeostasis by promoting N-glycosylation of CNNM proteins, which affects Mg2+ uptake in kidney cancer cells.

bioRxiv · Sep 9, 2020Biochemistry

Stress-induced tyrosine phosphorylation of RtcB modulates IRE1 activity and signaling outputs.

A. Papaioannou, F. G. Centonze, A. Metais, M. Maurel, L. Negroni, M. Gonzales-Quiroz, E. Zare Golchesmeh, A. Blondel, A. C. Koong, C. Hetz, R. Pedeux, M. L. Tremblay, S. J. Mahdizadeh, G. Svensson, L. A. Eriksson, e. chevet

This study identifies RtcB tyrosine phosphorylation as a regulatory mechanism controlling IRE1's dual RNase activities, influencing cell survival or death during ER stress.

bioRxiv · Mar 2, 2020Biochemistry

The Autoimmune Susceptibility Gene, PTPN2, Restricts Expansion of a Novel Mouse Adherent-Invasive E. coli

A. Shawki, R. Alvarez, M. R. Spalinger, P. M. Ruegger, A. Sayoc, A. N. Santos, P. Chatterjee, J. Mitchell, J. Macbeth, M. L. Tremblay, A. Hsiao, J. Borneman, D. F. McCole

This study shows PTPN2 deficiency in mice promotes expansion of a novel adherent-invasive E. coli that worsens colitis.

bioRxiv · Jul 22, 2019Microbiology