ImmunologybioRxiv
Lack of phosphatidylinositol 3-kinase VPS34 in regulatory T cells leads to a fatal lymphoproliferative disorder without affecting their development
C. J. Courreges, E. C. Davenport, B. Bilanges…·K. Okkenhaug
This study shows that VPS34 deficiency in regulatory T cells causes a fatal lymphoproliferative disorder by impairing metabolic and functional processes, despite normal development and in vitro suppression.
DOI 10.3389/fimmu.2024.1374621