Author

B. Bilanges

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:metabolism & bioenergetics· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1

Frequent Co-Authors

B. Vanhaesebroeck· 2 shared A. Strickaert· 1 shared C. J. Courreges· 1 shared C. Maenhaut· 1 shared C. Pierreux· 1 shared C. Scudamore· 1 shared C. Spourquet· 1 shared C.-Y. Chung· 1 shared

Activity by Year

2019-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersImmunology

B. Vanhaesebroeck

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3 papers

Recent·Most cited

Lack of phosphatidylinositol 3-kinase VPS34 in regulatory T cells leads to a fatal lymphoproliferative disorder without affecting their development

C. J. Courreges, E. C. Davenport, B. Bilanges, E. Rebollo-Gomez, J. Hukelmann, P. Schoenfelder, J. R. Edgar, D. Sansom, C. Scudamore, R. Roychoudhuri, O. A. Garden, B. Vanhaesebroeck, K. Okkenhaug

This study shows that VPS34 deficiency in regulatory T cells causes a fatal lymphoproliferative disorder by impairing metabolic and functional processes, despite normal development and in vitro suppression.

bioRxiv · Jan 8, 2024Immunology

Constitutive activation of the PI3K-Akt-mTORC1 pathway sustains the m.3243A>G mtDNA mutation

C.-Y. Chung, K. Singh, V. N. Kotiadis, G. E. Valdebenito, J. H. Ahn, E. Topley, J. Tan, W. D. Andrews, B. Bilanges, R. D. S. Pitceathly, G. Szabadkai, M. Yuneva, M. R. Duchen

The paper shows that the m.3243A>G mtDNA mutation activates the PI3K-Akt-mTORC1 pathway, which can be inhibited to reduce mutant mtDNA load and improve cellular function.

bioRxiv · Jun 18, 2020 · PreprintCell Biology

Vps34 PI 3-kinase controls thyroid hormone production by regulating thyroglobulin iodination, lysosomal proteolysis and tissue homeostasis

G. Grieco, T. Wang, O. Delcorte, V. Janssens, C. Spourquet, A. Strickaert, H. Gaide-Chevronnay, X.-H. Liao, B. Bilanges, S. Refetoff, B. Vanhaesebroeck, C. Maenhaut, P. Courtoy, C. Pierreux

bioRxiv · Jul 9, 2019Cell Biology