Cancer BiologybioRxiv
Glioma-derived CCL2 and CCL7 mediate migration of immune suppressive CCR2+ myeloid cells into the tumor microenvironment in a redundant manner
G. P. Takacs, C. J. Kreiger, D. Luo…·J. K. Harrison
This study shows that CCL2 and CCL7 from gliomas redundantly recruit CCR2+/CX3CR1+ myeloid cells into the tumor microenvironment, contributing to immune suppression and poor prognosis in GBM.
DOI 10.3389/fimmu.2022.993444