J. S. Garcia

Glioma-derived M-CSF and IL-34 license M-MDSCs to suppress CD8+ T cells in a NOS-dependent manner

This study identifies M-CSF and IL-34 as drivers of M-MDSC differentiation and T cell suppression in glioblastoma, with NOS involvement and microenvironmental niches contributing to M-MDSC heterogeneity.

Floral Cues and Flower Handling Tactics Affect Switching Decisions by Nectar-Foraging Bumble Bees

This study shows that bumble bees prefer to switch flower colors while keeping their handling tactics, but switch tactics when colors are very different and they have experience with legitimate visitation.

Systemically targeting monocytic MDSCs using dendrimers and their cell-level biodistribution kinetics

This study examines how hydroxyl dendrimers are taken up by M-MDSCs in tumor and lymphoid organs, showing differential uptake based on dendrimer functionality and serum proteins.

Glioma-derived CCL2 and CCL7 mediate migration of immune suppressive CCR2+ myeloid cells into the tumor microenvironment in a redundant manner

This study shows that CCL2 and CCL7 from gliomas redundantly recruit CCR2+/CX3CR1+ myeloid cells into the tumor microenvironment, contributing to immune suppression and poor prognosis in GBM.

BCOR and BCORL1 mutations disrupt PRC1.1 repressive function in leukemia by unlinking the RING-PCGF1 enzymatic core from target genes

This study shows BCOR and BCORL1 mutations disrupt PRC1.1 function in leukemia by separating its enzymatic core from chromatin targets, leading to treatment resistance.

Reconstructing the lineage histories and differentiation trajectories of individual cancer cells in JAK2-mutant myeloproliferative neoplasms

This study reconstructs the lineage histories and differentiation trajectories of JAK2-mutant HSCs in MPN patients, finding the mutation occurs decades before diagnosis and drives exponential growth of mutated HSC populations.