D. Luo

Mapping the genetic landscape establishing a tumor immune microenvironment favorable for anti-PD-1 response in mice and humans

The paper identifies host genetic factors influencing anti-PD-1 response in mice and humans by mapping QTLs and finding a core gene network with prognostic value in human tumors.

Synergically enhanced anti-tumor immunity of in vivo CAR by circRNA vaccine boosting

This study develops circRNA-based in vivo CAR and vaccines that synergistically enhance anti-tumor immunity in mice.

Biochemical characterization of extended-spectrum β-lactamases from Akkermansia genus

The paper characterizes β-lactamases from Akkermansia species, showing they exhibit extended-spectrum activity and lack transferable resistance genes.

Nonnative Fish in the Pearl River Delta: A Comprehensive Study on Their Salinity Adaptability and Potential Distribution Area in Brackish Water

Dispersal and evolution of the invasive snail Pomacea canaliculata, an intermediate host of Angiostrongylus cantonensis: A field study around its initial introduction site in China

This study investigates the spatial distribution, phenotypic variation, and dispersal patterns of the invasive snail Pomacea canaliculata in China, revealing human-mediated evolution and potential complexities in parasite transmission.

Concerns on research history overview, distribution patterns, and potentially neglected ecological consequences of the invasive apple snail (Pomacea sp.): A review

This paper reviews the research history, distribution, and ecological impacts of invasive apple snails, highlighting gaps in understanding and the need for further study.

Hyperosmolality tolerance of freshwater largemouth bass (Micropterus salmoides) to brackish at early ontogenetic stages: Eggs, embryos and yolk-sac larvae

This study examines the hyperosmolality tolerance of freshwater largemouth bass during early life stages, revealing osmoregulatory responses and survival impacts under varying salinity conditions.

Serine hydroxymethyl transferase is a binding target of caprylic acid: Uncovering a novel molecular target for a herbicide and for producing caprylic acid-tolerant crops

This study identifies serine hydroxymethyl transferase (SHMT) as a binding target of caprylic acid, showing its role in herbicidal activity and potential for developing tolerant crops.

FrameDiPT: SE(3) Diffusion Model for Protein Structure Inpainting

FrameDiPT is a diffusion model for protein structure inpainting that recovers masked sections using sequence and structural context, achieving comparable accuracy to existing models with limited data.

Immunosuppressive tumor microenvironment of osteosarcoma

This study identifies immunosuppressive mechanisms in osteosarcoma using single-cell and spatial transcriptomics, revealing interactions between MDSCs, T-cells, and tumor cells that promote an immunosuppressive microenvironment.

Xylazine co-self-administration suppresses fentanyl consumption during self-administration and induces a unique sex-specific withdrawal syndrome that is not altered by naloxone in rats

This study shows that xylazine reduces fentanyl self-administration in rats and causes sex-specific withdrawal symptoms not affected by naloxone.

A Deep Learning Approach for Histology-Based Nuclei Segmentation and Tumor Microenvironment Characterization

This study introduces HD-Yolo, a deep learning method for faster and more accurate nuclei segmentation and tumor microenvironment quantification in whole-slide images.

HSPB1 facilitates chemoresistance through inhibiting ferroptotic cancer cell death and regulating NF-κB signaling pathway in breast cancer

This study identifies HSPB1 as a driver of chemoresistance in breast cancer by inhibiting ferroptosis and activating NF-κB signaling.

Glioma-derived CCL2 and CCL7 mediate migration of immune suppressive CCR2+ myeloid cells into the tumor microenvironment in a redundant manner

This study shows that CCL2 and CCL7 from gliomas redundantly recruit CCR2+/CX3CR1+ myeloid cells into the tumor microenvironment, contributing to immune suppression and poor prognosis in GBM.

Crystal structure of the Rubella virus protease reveals a unique papain-like protease fold

This paper reports the crystal structure of Rubella virus protease and demonstrates its protease and deubiquitylation activities, providing insights for antiviral drug development.

Molecular Architecture of the Chikungunya Virus Replication Complex

This study determines the structure of the chikungunya virus replication complex at near-atomic and subnanometer resolution, revealing its molecular architecture and implications for antiviral therapy.

Secreted dengue virus NS1 from infection is predominantly dimeric and in complex with high-density lipoprotein

The paper determines the structure of secreted dengue virus NS1 from infected cells, showing it forms dimers complexed with HDL.

Covalent inhibition of endoplasmic reticulum chaperone GRP78 disconnects the transduction of ER stress signals to inflammation and lipid accumulation in diet-induced obese mice

OsSWEET11b, a sixth leaf blight susceptibility gene involved in sugar transport-dependent male fertility

The paper identifies OsSWEET11b as a rice gene involved in male fertility and susceptibility to bacterial leaf blight, showing its role in sucrose transport and Xoo virulence.

ASER: Animal Sex Reversal database

ASER compiles sex reversal data from 18 species, including genes, regulatory networks, RNA-seq, and ISH images, to support research on animal breeding and human health.

Species-specific molecular barriers to SARS-CoV-2 replication in bat cells

The paper investigates SARS-CoV-2 replication in bat cells and finds species-specific molecular barriers, with some cells controlling viral replication after human ACE2 expression.

Broad neutralization against SARS-CoV-2 variants induced by a modified B.1.351 protein-based COVID-19 vaccine candidate

This study evaluates a modified B.1.351 spike trimer vaccine candidate, showing it induces broad neutralization against multiple SARS-CoV-2 variants in mice.

Structural insights into the role of Dicer-related helicase 3 in RNAi in Caenorhabditis elegans.

This study determines the crystal structures of DRH-3 domains bound to RNA, revealing structural features that explain its role in RNAi and evolutionary divergence from Dicer-like helicases.

S-Trimer, a COVID-19 subunit vaccine candidate, induces protective immunity in nonhuman primates

This study evaluates S-Trimer, a subunit vaccine candidate for COVID-19, showing it induces protective immunity in nonhuman primates with adjuvants.

Immune elicitation by sensing the conserved signature from phytocytokines and microbes via the Arabidopsis MIK2 receptor

The paper identifies MIK2 as a plant receptor that recognizes conserved peptide motifs from phytocytokines and microbial proteins, triggering immune responses through a signaling relay.

Population Differentiation of Rhodobacteraceae Along Coral Compartments

This study examines how different coral compartments shape microbial evolution by analyzing genome sequences of Rhodobacteraceae in mucus and skeleton, identifying genetic adaptations to compartment-specific environments.

Visualizing and isolating iron-reducing microorganisms at single cell level

This paper develops a fluorescent chemodosimeter to visualize and isolate iron-reducing microorganisms at the single-cell level, demonstrating its effectiveness in identifying active FeRM from complex samples.

Single-cell multimodal glioma analyses reveal epigenetic regulators of cellular plasticity and environmental stress response

The paper integrates multi-omic data from gliomas to show that epigenetic instability and transcriptional disruption are linked to tumor aggressiveness and environmental stress response.

Discovery of protein modifications using high resolution differential mass spectrometry proteomics

This paper introduces SAMPEI, a spectral alignment method for detecting protein modifications using high-resolution mass spectrometry, demonstrating its effectiveness in identifying sub-stoichiometric modifications in mouse macrophages.

Rapid adaptation of SARS-CoV-2 in BALB/c mice: Novel mouse model for vaccine efficacy

This paper develops a novel mouse model for SARS-CoV-2 infection and evaluates the protective efficacy of an RBD-based subunit vaccine.