The NLRP3 inflammasome is essential for IL-18 production in a murine model of macrophage activation syndrome.
T. A. Gleeson, C. Kaiser, C. B. Lawrence, D. Brough, S. M. Allan, J. P. Green
This study shows the NLRP3 inflammasome is crucial for IL-18 production in a murine model of MAS but not for other disease features.
bioRxiv · Feb 27, 2024Immunology