J. P. Green

The paper investigates the nuclear role of pro-IL-1 and evolutionary changes in its NLS and HAT-binding domains using proximity labelling and mutation analysis.

This study shows stroke triggers inflammasome-dependent atherosclerotic plaque rupture, leading to recurrent stroke, and identifies DNA-mediated inflammasome activation as a therapeutic target.

The paper identifies inhibitors of DNA sensors like AIM2, cGAS, and TLR9, including 4-sulfonic calixarenes and suramin, showing potential for treating DNA-driven inflammatory diseases.

This paper derives inclusive fitness forces of selection in social species, showing that selection on survival can persist post-reproduction and reproductive selection may not decline monotonically.

This study shows itaconate and fumarate derivatives inhibit both priming and activation of NLRP3 inflammasome in macrophages and microglia, suggesting their therapeutic potential for NLRP3-driven diseases.

This study identifies LRRC8A as a key regulator of hypotonicity-induced NLRP3 inflammasome activation, distinct from DAMP-induced activation.