H. Schmidt

The replicative helicase CMG is required for the divergence of cell fates during asymmetric cell division in vivo

The paper identifies a role for the CMG helicase in promoting transcriptional divergence during asymmetric cell division in C. elegans, independent of its DNA unwinding function.

A regression based approach to phylogenetic reconstruction from multi-sample bulk DNA sequencing of tumors

This paper introduces fastBE, a method for phylogenetic reconstruction from bulk DNA sequencing data that improves accuracy and scalability over existing approaches.

Unexpectedly dense colonization of soil pore space by microbes

The paper challenges the notion of sparse microbial colonization in soil by showing higher microbial densities and simulating their distribution in soil pore space.

Age-Related Dynamics of Methanogenic Archaea in the Human Gut Microbiome: Implications for Longevity and Health

This study examines age-related changes in methanogenic archaea in the human gut microbiome, finding that centenarians have a methanogen composition similar to younger adults and that Ca. M. intestini plays a key role in network stability.

Molecular determinants of SEC61A1 mutant R236C in two patient-derived cellular platforms

The paper assesses the molecular phenotype of SEC61A1 R236C mutation in two patient-derived cellular models, finding reduced autophagy, cAMP synthesis, and increased calcium leakiness, with similar overall effects across cell types.

Bacteria face trade-offs in the decomposition of complex biopolymers

This paper uses theoretical modeling to show that microorganisms face trade-offs in producing exo- or endo-enzymes for biopolymer decomposition, affecting their growth under different substrate conditions and community dynamics.

Open-loop lab-on-a-chip technology enables remote computer science training in Latinx life sciences students

This paper demonstrates that lab-on-a-chip technology combined with internet-based project-based learning can effectively train Latinx students in computational biology and increase their interest in STEM careers.

Nanopore adaptive sampling of a metagenomic sample derived from a human monkeypox case

The paper uses Nanopore sequencing to analyze a monkeypox sample, enabling real-time viral genome characterization and strain determination.

The Ribosome Maturation Factor Rea1 utilizes nucleotide independent and ATP hydrolysis driven Linker remodelling for the removal of ribosome assembly factors

This study investigates how Rea1 removes ribosome assembly factors by showing its linker undergoes nucleotide-independent and ATP hydrolysis-driven remodelling to interact with the MIDAS domain.

In vitro characterization of the full-length human dynein-1 cargo adaptor BicD2

This study characterizes full-length human BicD2 using biochemical and biophysical methods, revealing its conformational changes and interactions with RanBP2.

Coordination of RNA and protein condensation by the P granule protein MEG-3

This study identifies the role of MEG-3's C-terminal HMGL domain in forming co-condensates with PGL proteins in C. elegans germ granules, independent of RNA.

Spontaneous restoration of functional β-cell mass in obese SM/J mice

This study shows that obese SM/J mice spontaneously recover β-cell mass and function, leading to normoglycemia, suggesting potential therapeutic strategies for diabetes.

Cutting out the middle clam: lucinid endosymbiotic bacteria are also associated with seagrass roots worldwide

The paper finds that seagrass roots globally host sulphur-oxidising bacteria, Ca. Thiodiazotropha, even in the absence of lucinid bivalves, suggesting seagrasses can mitigate sulphide stress independently.

Brown adipose expansion and remission of glycemic dysfunction in obese SM/J mice

This study shows that obese SM/J mice spontaneously resolve glycemic dysfunction through brown adipose expansion, with associated transcriptomic and physiological changes.

IQ-TREE 2: New models and efficient methods for phylogenetic inference in the genomic era

IQ-TREE 2 introduces new models and efficient methods for phylogenetic inference, improving upon its previous version for genomic data analysis.

Development of a Confinable Gene-Drive System in the Human Disease Vector, Aedes aegypti.

This paper develops CRISPR-based split-gene drives in Aedes aegypti with high cleavage and transmission rates, demonstrating their potential for safe and reversible population control.

Flotillin-dependent lipid-raft microdomains are required for functional phagolysosomes against fungal infections

This study shows that flotillin-dependent lipid rafts are essential for phagolysosomal function against fungal infections, with implications for human susceptibility to aspergillosis.

The genomic footprint of climate adaptation in Chironomus riparius

This study identifies 162 candidate genes associated with climate adaptation in Chironomus riparius using population genomic analysis and environmental association.

Dephosphorylation is the Mechanism of Fibroblast Growth Factor Inhibition of Guanylyl Cyclase-B

This study identifies dephosphorylation as the mechanism by which fibroblast growth factor 2 inhibits guanylyl cyclase-B in rat chondrosarcoma cells.