Author

C. Kersten

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cancer Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Assay:metabolomics· 1

Frequent Co-Authors

T. Schirmeister· 2 shared A. Bauer· 1 shared A. Georgakopoulou· 1 shared A. H. Kostner· 1 shared A. Hayday· 1 shared A. Jandke· 1 shared A. Kilbey· 1 shared A. Roseweir· 1 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersMicrobiology

T. Schirmeister

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

β-catenin obstructs γδ T cell immunosurveillance in colon cancer through loss of BTNL expression

T. Suzuki, A. Kilbey, R. A. Ridgway, H. Hayman, R. Byrne, N. Casa Rodriguez, A. Georgakopoulou, L. Chen, M. Verzi, D. M. Gay, E. G. Vzquez, H. L. Belnoue-Davis, K. Gilroy, A. H. Kostner, C. Kersten, , S. B. Coffelt

This study shows that β-catenin signaling in colon cancer cells reduces BTNL expression, impairing γδ T cell immunosurveillance and promoting tumor progression.

bioRxiv · Jun 10, 2022 · PreprintCancer Biology

Identification, Characterization and Synthesis of Natural Parasitic Cysteine Protease Inhibitors -- More Potent Falcitidin Analogs

S. Brinkmann, S. Semmler, C. Kersten, M. A. Patras, M. Kurz, N. Fuchs, S. J. Hammerschmidt, J. Legac, P. E. Hammann, A. Vilcinskas, P. J. Rosenthal, T. Schirmeister, A. Bauer, T. F. Schaeberle

The paper identifies and synthesizes natural falcitidin analogs with enhanced inhibitory activity against parasitic cysteine proteases.

bioRxiv · Oct 30, 2021 · PreprintMicrobiology

Structure, interdomain dynamics and pH-dependent autoactivation of pro-rhodesain, the main lysosomal cysteine protease from African trypanosomes

P. Johe, E. Jaenicke, H. Neuweiler, T. Schirmeister, C. Kersten, U. A. Hellmich

This study determines the crystal structure of pro-rhodesain, identifies interdomain dynamics, and reveals a pH-dependent autoactivation mechanism in trypanosomal cathepsin L-like proteases.

bioRxiv · Nov 10, 2020Biochemistry