Author

T. Schirmeister

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:drug response / drug discovery· 1 Assay:metabolomics· 1 Research Focus:protein folding & dynamics· 1 Assay:structural biology· 1

Frequent Co-Authors

C. Kersten· 2 shared A. Bauer· 1 shared A. Vilcinskas· 1 shared E. Jaenicke· 1 shared H. Neuweiler· 1 shared J. Legac· 1 shared M. A. Patras· 1 shared M. Kurz· 1 shared

Activity by Year

2020-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersMicrobiology

C. Kersten

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2 papers

Recent·Most cited

MicrobiologybioRxivPreprintOct 30, 2021

Identification, Characterization and Synthesis of Natural Parasitic Cysteine Protease Inhibitors -- More Potent Falcitidin Analogs

S. Brinkmann, S. Semmler, C. Kersten…·T. F. Schaeberle

The paper identifies and synthesizes natural falcitidin analogs with enhanced inhibitory activity against parasitic cysteine proteases.

DOI 10.1101/2021.10.30.466580

metabolomicsexperimental assay

𝕏 PostBluesky

BiochemistrybioRxivNov 10, 2020

Structure, interdomain dynamics and pH-dependent autoactivation of pro-rhodesain, the main lysosomal cysteine protease from African trypanosomes

P. Johe, E. Jaenicke, H. Neuweiler…·U. A. Hellmich

This study determines the crystal structure of pro-rhodesain, identifies interdomain dynamics, and reveals a pH-dependent autoactivation mechanism in trypanosomal cathepsin L-like proteases.

DOI 10.1016/j.jbc.2021.100565

structural biologyexperimental assay

𝕏 PostBluesky