C. L. Berger

Modification of the Neck Linker of KIF18A Alters Microtubule Subpopulation Preference

This study shows that a phosphomimetic mutation in KIF18A's neck-linker alters its localization to microtubule subpopulations, affecting mitotic spindle positioning and progression.

The sets of kinesins and dynein transporting endocytic cargoes determine the effect of tau on their motility

The paper investigates how different motor protein sets on endocytic cargoes influence their motility and response to tau, finding that tau inhibits retrograde transport of early phagosomes more than late phagosomes.

Tau differentially regulates the transport of early endosomes and lysosomes

This study shows that tau differentially regulates the transport of early endosomes and lysosomes by inhibiting kinesin motors, with lysosomes being more affected than early endosomes.

The Pathogenic R5L Mutation Disrupts Formation of Tau Complexes on the Microtubule by Altering Local N-Terminal Structure

This paper investigates the R5L mutation in Tau, showing it does not reduce microtubule-binding affinity but alters N-terminal structure, impairing Tau complex formation on microtubules.

The Microtubule Associated Protein Tau Regulates KIF1A Pausing Behavior and Motility

This paper identifies Tau-mediated regulation of KIF1A pausing behavior and motility through competitive interaction with tubulin C-terminal tails, linking it to neurodegenerative disease mechanisms.

Individual Molecular Motors use Low Forces to bypass Roadblocks during Collective Cargo Transport

The paper measures forces exerted by individual kinesin motors during cargo transport, finding they exert less than a piconewton even when bypassing obstacles.

The Human Kinesin Kif18A’s Neck Linker Permits Navigation of Microtubule Bound Obstacles within the Mitotic Spindle

This study shows that the long neck linker of Kif18A enables it to navigate microtubule-associated protein obstacles to accumulate at K-fiber plus-ends during mitosis.

Tau directs intracellular trafficking by regulating the forces exerted by kinesin and dynein teams

This study shows tau modulates intracellular transport by biasing bidirectional motility toward the microtubule minus-end through motor-specific regulation of kinesin and dynein forces.