Author

M. J. Previs

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biophysics· 2 Physiology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 5 Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Organism:human· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:clustering· 1

Frequent Co-Authors

T. S. O'Leary· 3 shared N. B. Wood· 2 shared A. Capilnasiu· 1 shared A. Cario· 1 shared A. G. Hendricks· 1 shared A. Li· 1 shared A. P. Liu· 1 shared A. S. Cornachione· 1 shared

Activity by Year

2019-2021 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersCell Biology

T. S. O'Leary

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

The Pathogenic R5L Mutation Disrupts Formation of Tau Complexes on the Microtubule by Altering Local N-Terminal Structure

A. Cario, A. Savastano, N. B. Wood, Z. Liu, M. J. Previs, A. G. Hendricks, M. Zweckstetter, C. L. Berger

This paper investigates the R5L mutation in Tau, showing it does not reduce microtubule-binding affinity but alters N-terminal structure, impairing Tau complex formation on microtubules.

bioRxiv · Oct 15, 2021Biophysics

The Skeletal Muscle Circadian Clock Regulates Titin Splicing Through RBM20

L. Riley, X. Zhang, C. Douglas, J. Mijares, D. Hammers, C. A. Wolff, N. B. Wood, H. Olafson, P. Du, S. Labeit, M. J. Previs, E. T. Wang, K. A. Esser

This study shows that the skeletal muscle circadian clock regulates titin splicing via RBM20, affecting sarcomere length and function.

bioRxiv · May 27, 2021Physiology

Biomechanics and Myofibrillar Alignment Enhance Contractile Development and Reproducibility in Stem Cell Derived Cardiac Muscle

Y.-C. Tsan, Y.-T. Zhao, S. J. DePalma, A. Capilnasiu, Y.-W. Wu, B. Elder, I. Panse, S. Friedline, T. S. O'Leary, N. Wubshet, K. K. Y. Ho, M. J. Previs, D. Nordsletten, B. M. Baker, L. L. Isom, , A. S. Helms

This study develops a 2D platform to enhance contractile development and reproducibility in stem cell-derived cardiac muscle by controlling biomechanics and myofibrillar alignment.

bioRxiv · May 23, 2021 · PreprintCell Biology

CryoEM Structure of Drosophila Flight Muscle Thick Filaments at 7A Resolution

N. Daneshparvar, D. W. Taylor, T. S. O'Leary, H. Rahmani, F. Abbasi Yeganeh, M. J. Previs, K. A. Taylor

The paper reports the 7Å resolution CryoEM structure of Drosophila flight muscle thick filaments, revealing conserved myosin tail arrangements and novel non-myosin densities.

bioRxiv · Jun 5, 2020Biophysics

SKELETAL MyBP-C ISOFORMS TUNE THE MOLECULAR CONTRACTILITY OF DIVERGENT SKELETAL MUSCLE SYSTEMS

A. Li, S. Nelson, S. Rahmanseresht, F. Braet, A. S. Cornachione, S. B. Previs, T. S. O'Leary, J. W. McNamara, D. E. Rassier, S. Sadayappan, M. J. Previs, D. M. Warshaw

This study examines how different MyBP-C isoforms affect contractility in fast- and slow-twitch skeletal muscles using proteomic, biophysical, and modeling approaches.

bioRxiv · Jun 21, 2019Physiology