BiophysicsbioRxiv
The Pathogenic R5L Mutation Disrupts Formation of Tau Complexes on the Microtubule by Altering Local N-Terminal Structure
A. Cario, A. Savastano, N. B. Wood…·C. L. Berger
This paper investigates the R5L mutation in Tau, showing it does not reduce microtubule-binding affinity but alters N-terminal structure, impairing Tau complex formation on microtubules.
DOI 10.1073/pnas.2114215119