In situ humoral selection in human lupus tubulointerstitial inflammation
A. J. Kinloch, Y. Asano, A. Mohsin, C. J. Henry, R. Abraham, A. Chang, C. Labno, P. C. Wilson, M. R. Clark
The paper shows that anti-vimentin antibodies in lupus nephritis undergo in situ selection for enhanced binding and specificity to vimentin fibrils, challenging the notion of affinity maturation as a non-specific consequence of polyreactivity.
bioRxiv · Jun 29, 2020 · PreprintImmunology